Osimertinib as adjuvant therapy in patients with resected EGFRm stage IB-IIIA NSCLC: updated results from ADAURA
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Hintergrund Osimertinib ist ein EGFR-TKI der 3. Generation, der EGFR-TKI sensitivierende und EGFR-T790M-Resistenzmutationen potent und selektiv hemmt. Osimertinib ist wirksam bei EGFRm NSCLC, einschließlich ZNS-Metastasierung. In der Primäranalyse der Phase-III-Studie ADAURA (NCT02511106) zeigte die adjuvante Gabe von Osimertinib einen signifikanten und klinisch bedeutsamen Vorteil im krankheitsfreien Überleben (DFS) gegenüber Placebo (PBO) bei Patienten mit R0-reseziertem EGFRm (Ex19del/L858R) NSCLC,±adj. Chemotherapie (CT): Stadium II–IIIA DFS HR, 0,17; 99,06% KI, 0,11, 0,26; p<0,0001; Stadium IB–IIIA DFS HR, 0,20; 99,12% KI 0,14, 0,30; p<0,0001. Wir berichten über explorative Analysen von DFS und Rezidivmustern nach 2 Jahren zusätzlichem Follow-up.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it