Fat‐1 transgenic mice endogenously synthesizing high levels of n−3 PUFA are resistant to pentylenetetrazol induced seizures
Bibliographic record
Abstract
Epilepsy is a serious neurological disorder which is characterized by spontaneous, recurrent seizures. Current medications have side effects including weight gain, fatigue and sedation. Omega‐3 (n−3) polyunsaturated fatty acids (PUFA), derived from marine fish oils, have been considered as an alternative treatment for patients with epilepsy. Accordingly, we hypothesized that enrichment of brain lipids with n−3 PUFA would inhibit the epileptic‐like seizures induced by pentylenetetrazol (PTZ). We demonstrate that the increased levels of n−3 PUFA in brain phospholipids of male and female transgenic Fat‐1 mice, which are capable of de novo synthesis of n−3 PUFA from n−6 PUFA, results in increased latency to seizure onset in males only (P<0.05 by 2‐way analysis of variance) . Latency to seizure onset was ~2‐fold longer in male Fat‐1 mice, as compared to male controls. Although not significant, the percentage of male and female mice that survived following the PTZ injection was also higher in Fat‐1 mice, as compared to controls (P=0.08 by chi‐squared test). These findings suggest that n−3 PUFA have anticonvulsant properties and would be potentially useful in the treatment of epilepsy.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.005 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".