Participation of reactive oxygen species in the pathogenesisof atopic dermatitis, allergic rhinitis and asthma
Bibliographic record
Abstract
Reactive oxygen species (ROS) are any usually highly reactive chemical compounds that contain an oxygen atom with an unpaired electron in their structure.In physiological conditions, they are involved in many metabolic reactions in the body, while they are also involved in the pathogenesis of diseases such as atopic dermatitis, allergic rhinitis and asthma.Excessive ROS and antioxidant barrier dysfunction cause oxidative stress, resulting in increased oxidative damage in cells, disruption of their proper functioning and induction of a chronic inflammatory process. Key woRdsatopic dermatitis, allergic rhinitis, asthma, reactive oxygen species.stReszczenie Reaktywne formy tlenu (RFT) to zwykle wysoce reaktywne związki chemiczne, które zawierają w swojej struk turze atom tlenu z niesparowanym elektronem.W warunkach fizjologicznych biorą udział w wielu reakcjach metabolicznych zachodzących w organizmie, ale uczestniczą także w patogenezie chorób, takich jak atopowe zapalenie skóry, alergiczny nieżyt nosa lub astma.Nadmierne wytwarzanie RFT i dysfunkcja bariery anty oksydacyjnej prowadzą do rozwoju stresu oksydacyjnego, co skutkuje zwiększeniem uszkodzeń oksydacyjnych w komórkach, zaburzeniem ich prawidłowego funkcjonowania oraz indukcją przewlekłego procesu zapalnego.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.004 | 0.002 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.003 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.017 | 0.008 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".