Assessing the Beclin-1 Knockout: Autophagy, Neurogenesis, and the TUNL Task
Bibliographic record
Abstract
Autophagy is the intracellular process of isolating, enveloping, and recycling cell matter.Beclin-1 is a protein that acts as a lynchpin in the autophagic process.Animals lacking Beclin-1 are embryonically lethal, and knockout of Beclin-1 causes a reduction in adult hippocampal neurogenesis.The dentate gyrus (DG) is normally home to ongoing neurogenesis, which is thought to mediate pattern separation and memory encoding.First, I test a new protocol for the TUNL task.To assess whether a behavioural phenotype of Beclin-1 nKO is apparent, on the second experiment I compare TUNL performance between WT and KO mice.The new protocol for the TUNL task produces a reliable measure of pattern separation.Beclin-1 nKO reduced DG neurogenesis by 40% compared to WT.No difference between the WT and KO mice in TUNL task performance (pattern separation ability) was found but KO mice had lower activity in the CA1 during the task.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".