MCI Conversion Prediction Using 3D Zernike Moments and the Improved Dynamic Particle Swarm Optimization Algorithm
Bibliographic record
Abstract
Mild cognitive impairment (MCI) conversion prediction is a vital challenge in the area of Alzheimer’s disease (AD) as it could determine possible treatment pathways for AD patients. In this work, we presented a robust MCI conversion prediction framework based on the 3D-Zernike Moment (3D-ZM) method that generates statistical features (e.g., shape, texture, and symmetry information) from 3D-MRI scans and improved dynamic particle swarm optimization (IDPSO) that finds an informative sub-set of Zernike features for MCI conversion prediction. We quantified the efficiency of the proposed prediction framework on a large sample of MCI patients including 105 progressive-MCI (pMCI) and 121 stable-MCI (sMCI) at the baseline from the ADNI dataset. Using the proposed MCI conversion prediction framework, pMCI patients were distinguished from sMCI patients with an accuracy exceeding 75% (sensitivity, 83%, and specificity, 68%), which is well comparable with the state-of-the-art MCI conversion prediction approaches. Experimental results indicate that the 3D-ZM method can represent informative statistical patterns from 3D-MRI scans and IDPSO has a great capability to find meaningful statistical features for identifying MCI patients who are at risk of conversion to the AD stage.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".