Membrane receptors mediate the rapid facilitation of <scp>short‐term</scp> memory by estradiol in the dorsal hippocampus of female mice
Bibliographic record
Abstract
Estrogens play a key role in learning and memory via delayed genomic and early-onset rapid mechanisms. Systemic treatment with 17β-estradiol (E2) rapidly facilitates object recognition, social recognition and object placement short-term memory in ovariectomized female mice within a timescale of only 40 min following administration. The dorsal hippocampus is one critical site of rapid estrogenic effects. Estrogen receptors (ER) are located in the cell nucleus, cytoplasm and membrane. Membrane ERs alone can mediate the rapid facilitation of long-term memory consolidation by estrogens. This study determined the role of membrane ERs in the rapid effects of 17-β estradiol (E2) on short-term memory within the dorsal hippocampus of ovariectomized mice. We infused E2 conjugated to bovine serum albumin (BSA-E2) that prevents it from crossing the cell membrane and found that the rapid facilitation by E2 of short-term memory in the social recognition, object recognition and object placement tasks is mediated by membrane ERs, independently of intracellular receptors.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".