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Record W4367047556 · doi:10.1093/cid/ciad252

Several Concerns With Doxycycline Meta-Analysis

2023· review· en· W4367047556 on OpenAlexaffabout
Thomas A Warren

Bibliographic record

VenueClinical Infectious Diseases · 2023
Typereview
Languageen
FieldMedicine
TopicPneumonia and Respiratory Infections
Canadian institutionsMcMaster University
FundersGilead SciencesNational Institutes of HealthPfizer
KeywordsMedicineBronchitisPneumoniaDoxycyclineAdverse effectMeta-analysisChronic bronchitisExacerbationSpiramycinInternal medicineAntibioticsErythromycin

Abstract

fetched live from OpenAlex

To the editor—I have several concerns regarding the article “Efficacy of Doxycycline for Mild-to-Moderate Community-Acquired Pneumonia in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials” by Choi et al [1]. In the study by Biermann et al [2], 221 patients were entered in a double-blind comparative study. A total of 191 patients were evaluated, 104 with pneumonia and 87 with exacerbation of bronchitis. The rates of cure and side effects for patients with bronchitis and pneumonia are reported; however, the number of patients with pneumonia given doxycycline (55) and the number of patients given spiramycin (49) reported by Choi et al in Table 1 of their article are not found in the Biermann et al article. Furthermore, it appears that Choi et al took the pneumonia cure rate (84%) and adverse effects rate (20%) reported by Biermann et al and applied them to doxycycline but applied the bronchitis cure rate (75%) and adverse effects rate (24%) to spiramycin. Choi et al report several numbers from Biermann et al that were not found in the original publication, so it is necessary for Choi et al to substantiate those numbers to justify inclusion of the Biermann article in their meta-analysis.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.354
metaresearch head score (Gemma)0.638
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesMetaresearch
DomainCandidate signal: Methods · Consensus signal: none
Study designCandidate signal: Systematic review · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.646
Threshold uncertainty score0.796

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.3540.638
Meta-epidemiology (narrow)0.0020.002
Meta-epidemiology (broad)0.0070.013
Bibliometrics0.0050.007
Science and technology studies0.0010.004
Scholarly communication0.0070.007
Open science0.0050.003
Research integrity0.0060.009
Insufficient payload (model declined to judge)0.0110.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.417
GPT teacher head0.527
Teacher spread0.110 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.

Study designSystematic review
DomainMethods
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes2
Has abstractyes

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