Description of cognitive and imaging function in a cohort of COVID-19 survivors in a tertiary hospital in Mexico City. (P2-12.007)
Bibliographic record
Abstract
Objective: DTo escribe cognitive function in COVID-19 survivors who may persist through long COVID-19, correlation with imaging lesions. Background: several studies have been done to describe them and to find the predisposing factors without finding the precise aetiology of these alterations. Design/Methods: Cohort of patients in 1 hospital in Mexico City who survived COVID-19 and were evaluated after 12 weeks of hospital discharge from December 2020 to April 2021, those with 26 points or less on MoCA test and/or cognitive complaint, underwent neuropsychological testing and cranial MRI. Those who had invasive mechanical ventilatory support (IMV) and those who had non-invasive mechanical ventilation (NMV-I) were classified into two groups. The main objective of this study was to describe cognitive function, its correlations with magnetic resonance imaging and markers of inflammation and functional status post COVID-19. Results: total 375 patients were evaluated, 315 were excluded for not meeting criteria and follow-up. 60 patients completed the study, 41 had VMI and 19 VMn-I patients, 66.6% where amle with a mean age 58.5, mean MoCA scale score 25.8. The VMn-I group presented higher scores on the FMVC scale (23.6 points) p=0.007. Failures in executive functions with the Trail Making Test in 33% of both groups, as well as in the Verbal Phonological Fluency test in 31.6% and in the attention domain with the Retention of Progressive Digits test in 26.8%, no statistical significance. Failures in attention and processing speed were associated with frontal atrophy, and failures in memory and executive functions were associated with frontotemporal atrophy (p=0.008 and 0.034 respectively). Other factors associated with functional disability were anxiety (p=<0.001), depression (p=<0.001), elevated D-dimer levels (p=0.002), increased days of intubation (p=0.005) and neuropathy (p=0.030). Conclusions: SARS CoV-2 infection leaves persistent symptoms in cognitive functions such as executive functions, attention and memory. These cognitive failures are independent of disease severity. Disclosure: Dr. Santos has nothing to disclose. Dr. Rodríguez has nothing to disclose. Dr. Arauz has nothing to disclose. Dr. Gutierrez Romero has nothing to disclose. Dr. Soto Moreno has nothing to disclose. Dr. Lopez Gonzalez has nothing to disclose. Yaneth Rodríguez Agudelo has nothing to disclose. Francisco Paz Rodriguez has nothing to disclose. Mireya Chávez Oliveros has nothing to disclose. Susana Lozano Tovar Susana has nothing to disclose. Dr. Del Rio Quiñones has nothing to disclose. Karina González Alonso has nothing to disclose. Roger Carrillo-Mezo has nothing to disclose. Oscar Marrufo Meléndez has nothing to disclose.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".