eLife Assessment: Tetraose steroidal glycoalkaloids from potato can provide complete protection against fungi and insects
Bibliographic record
Abstract
Plants with innate disease and pest resistance can contribute to more sustainable agriculture. Plant breeders typically focus on immune receptors or impaired susceptibility genes to develop resistant crops, but these can present challenges in terms of strength, durability or pleotropic effects. Although natural defence compounds produced by plants have the potential to provide a general protective effect against pathogens and pests, they are not a primary target in resistance breeding. The precise contribution of defence metabolites to plant immunity is often unclear and the genetics underlying their biosynthesis is complex. Here, we identified a wild relative of potato, Solanum commersonii, that provides us with unique insight in the role of glycoalkaloids in plant immunity. We cloned two atypical resistance genes that can provide complete resistance to Alternaria solani and Colorado potato beetle through the production of tetraose steroidal glycoalkaloids. Moreover, we show that these compounds are active against a wide variety of fungi. This research provides a direct link between specific modifications to steroidal glycoalkaloids of potato and resistance against diseases and pests. Further research on the biosynthesis of plant defence compounds in different tissues, their toxicity, and the mechanisms for detoxification, can aid the effective use of such compounds to improve sustainability of our food production.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".