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Molecular species composition of polar lipids from two microalgae Nitzschia palea and Scenedesmus costatus using HPLC-ESI-MS/MS

2023· preprint· en· W4368371185 on OpenAlexaff
Nicolás Mazzella, Mariem Fadhlaoui, Aurélie Moreira, Soizic Morin

Bibliographic record

VenueChemRxiv · 2023
Typepreprint
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicMetabolomics and Mass Spectrometry Studies
Canadian institutionsInstitut National de la Recherche Scientifique
FundersAgence Nationale de la Recherche
KeywordsGalactolipidGalactolipidsAlgaeFatty acidPolyunsaturated fatty acidDegree of unsaturationScenedesmusDiatomChlorophytaChemistryBiologyLipidomicsBotanyBiochemistryChromatographyPhospholipidChloroplastMembrane

Abstract

fetched live from OpenAlex

This work reports the polar lipid profiles of two freshwater algae: the diatom Nitzschia palea, widespread alga that typically inhabits freshwater ponds and rivers, and the Scenedesmus costatus, a common green alga. HILIC-ESI-MS/MS analysis was used to determine and quantify the major phospholipids and glycolipids, and their relative molecular species, extracted from the two microalgal cultures. Glycolipids were eluted first, followed by phospholipids partially co-eluting with the sulfoglycolipids. We also studied the fragmentation pattern in the negative ionization mode for galactolipids. The most intense daughter ion corresponded to the fatty acyl chain located at the sn-2 position, which allowed us to determine the stereospecific distribution of the following fatty acids on the glycerol backbone. For green algae, 18:3 fatty acid was frequently occurring in both phospholipids and galactolipids. We also found 16:4 in some molecular species of mono- and digalactosyldiacylglycerol (MGDG and DGDG). The most abundant and characteristic molecular species of MGDG in green algae exhibited the combination (18:3/16:4), whereas DGDG was more saturated than MGDG and contained mainly 18:1, 18:2, or 18:3 at sn-1 and shorter fragments 16:0, 16:1, 16:2, and 16:3 at sn-2. It is also remarkable that in the diatom, the phospholipids contained mainly molecular species with saturated or monounsaturated fatty acids such as 16:0, 16:1 and 18:1. In contrast, MGDG and DGDG contained a higher proportion of polyunsaturated fatty acids, such as the unique and abundant MGDG (20:5/20:2).

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.012
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.001
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.023
GPT teacher head0.264
Teacher spread0.241 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2023
Admission routes1
Has abstractyes

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