Daily gabapentin improved behavior modification progress and decreased stress in shelter cats from hoarding environments in a double-blind randomized placebo-controlled clinical trial
Bibliographic record
Abstract
OBJECTIVE: To evaluate the impact of daily gabapentin on behavior modification progression and signs of stress in fearful shelter cats from hoarding environments. ANIMALS: 37 cats (32 met inclusion criteria). PROCEDURES: Healthy fearful cats were entered into group (1) gabapentin or (2) placebo upon intake. Both groups received daily behavior modification. Cats received 10 mg/kg of liquid gabapentin or placebo every 12 hours. Daily measures of cat stress score, latency to emerge from hiding, general in-shelter behavior, and urine suppression were collected. Results were analyzed on an intention-to-treat and per-protocol basis (including only cats that received > 75% of their doses). Post-adoption surveys assessed cat social behavior. RESULTS: Of 32 fearful cats, 28 (87.5%) graduated from the behavior modification program in a median of 11 days (range, 4 to 51 days). Per-protocol analysis showed that gabapentin predicted quicker behavior modification progression and lower cat stress score, latency to emerge, and urine suppression compared to placebo. Median time to graduation was reduced by half with gabapentin. Intention-to-treat analysis showed that gabapentin predicted a lower cat stress score and latency to emerge. No differences were observed between groups for general in-shelter behavior. Among limited survey respondents (n = 7), despite showing unsocial behavior in the first week and among unfamiliar people, cats showed social behavior 1 year post-adoption. CLINICAL RELEVANCE: Daily gabapentin was beneficial in behavior modification progress and reduced signs of stress in shelter cats. Fearful cats from hoarding environments can be successfully treated with behavior modification ± daily gabapentin within an animal shelter.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".