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Record W4375859145 · doi:10.1038/s41588-023-01384-0

Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries

2023· article· en· W4375859145 on OpenAlexaff
Zhanju Liu, Ruize Liu, Han Gao, Seulgi Jung, Xiang Gao, Ruicong Sun, Xiaoming Liu, Yong‐Jae Kim, Ho‐Su Lee, Yosuke Kawai, Masao Nagasaki, Junji Umeno, Katsushi Tokunaga, Yoshitaka Kinouchi, Atsushi Masamune, Wenzhao Shi, Chengguo Shen, Zhenglin Guo, Kai Yuan, María T. Abreu, Jean–Paul Achkar, Vibeke Andersen, Çharles N. Bernstein, Steven R. Brant, Luís Bujanda, Siew C. Ng, Lee A. Denson, Richard H. Duerr, Lynnette R. Ferguson, Denis Franchimont, André Franke, Richard B. Gearry, Håkon Håkonarson, Jonas Halfvarson, Caren Heller, Antonio Julià, Judith R. Kelsen, Hamed Khalili, S. Kugathasan, Juozas Kupčinskas, Anna Latiano, Édouard Louis, Reza Malekzadeh, Jacob L. McCauley, Christopher J. Moran, David Okou, Tim Orchard, Aarno Palotie, Miles Parkes, Joel Pekow, Uroš Potočnik, Graham Radford‐Smith, John D. Rioux, Gerhard Rogler, Bruce E. Sands, Mark S. Silverberg, Harry Sokol, Séverine Vermeire, Rinse K. Weersma, Ramnik J. Xavier, Naizhong Hu, Qian Cao, Yufang Wang, Yinglei Miao, Hongjie Zhang, Xiaoping Lv, Hu Zhang, Jingling Su, Bai–Sui Feng, Ye Zhao, Liangru Zhu, Yan Chen, Lanxiang Zhu, Chunxiao Chen, Yali Wang, Ying-De Wang, Zhi Pang, Yingxuan Chen, Xiaolan Zhang, Hui Li, Yu Qin, Mei Ye, Sumin Zhang, Wen Tang, Mei Wang, Xiaocang Cao, Ruixin Zhu, Guangxi Zhou, Zhaolian Bian, Xiao‐Feng Guo, Xiaoli Wu, Jinchun Liu, Wei Xu, Yuqin Li, Qin Guo, Zhiguo Guo, Shu Zhu, Dalin Li, Jianjun Liu, Tian Ge, Judy H. Cho, Mark J. Daly, Dermot McGovern, Byong Duk Ye, Kyuyoung Song, Yoichi Kakuta, Mingsong Li, Hailiang Huang

Bibliographic record

VenueNature Genetics · 2023
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicInflammatory Bowel Disease
Canadian institutionsMontreal Heart InstituteMount Sinai HospitalUniversity of Manitoba
FundersSchool of Life Sciences and Biotechnology Division of Life Sciences, Korea UniversityJapan Society for the Promotion of ScienceUniversity of Science and Technology of ChinaNational Human Genome Research InstituteGenome Institute of SingaporeNational Research Foundation of KoreaNational Natural Science Foundation of ChinaNational University of SingaporeNational Research FoundationMassachusetts General HospitalHelsinki Institute of Life Science, Helsingin YliopistoNational Center for Global Health and MedicineNational Institute of Diabetes and Digestive and Kidney DiseasesStanley Center for Psychiatric Research, Broad InstituteKelaGuangzhou Medical UniversityBroad InstituteCedars-Sinai Medical CenterJapan Agency for Medical Research and DevelopmentTongji UniversityUniversity of UlsanHelsingin Yliopisto
KeywordsBiologyInflammatory bowel diseaseGenetic architectureInflammatory Bowel DiseasesGeneticsComputational biologyEvolutionary biologyDiseaseGenePhenotypeMedicineInternal medicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score0.011

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.002
Science and technology studies0.0010.001
Scholarly communication0.0010.000
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.005
GPT teacher head0.232
Teacher spread0.227 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations218
Published2023
Admission routes1
Has abstractno

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