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Record W4376116762 · doi:10.1017/cjn.2022.294

Charting the Neuroethics Landscape for Neuromodulation in Canada and Beyond

2023· article· en· W4376116762 on OpenAlexafffundvenueabout
Nir Lipsman, Patrick J. McDonald

Bibliographic record

VenueCanadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · 2023
Typearticle
Languageen
FieldNeuroscience
TopicNeuroethics, Human Enhancement, Biomedical Innovations
Canadian institutionsHealth Sciences CentreUniversity of ManitobaSunnybrook Health Science Centre
FundersSunnybrook Research InstituteFocused Ultrasound FoundationVancouver Coastal Health Research InstituteDana Foundation
KeywordsContent (measure theory)NeuromodulationAction (physics)NeuroethicsPsychologyNeuroscience

Abstract

fetched live from OpenAlex

The last two decades have seen an exponential rise in the science of neuromodulation and neurotechnology.Driven by advances in imaging, safer and more effective technology, and demographic shifts that have made brain diseases among the most common human afflictions, novel ways to directly influence function have emerged as dominant themes in the clinical neurosciences.Alongside the hope with these advances, however, many questions exist.Among them: What are ethical ways to translate new knowledge about basic mechanisms to clinical utility?What is the influence of placebo effects?What are the correct definitions of clinically useful and culturally meaningful outcomes?Permeating the field, including these questions, are the ethical implications of a new science of the brain, one where technology is used to directly influence critical brain functions, ostensibly to treat, but with the potential to do more and be more intimately integrated into vital brain functions.It is from this idea that neuroethics was developed; namely, that as the ability to interact with the brain, to image, measure, probe, and modulate its function, improves, critical questions will arise not only about what we can do, but whether and how we ought to in the first place.At its core, neuroethics is the study of how scientists and clinicians and patients view their relationship with the brain, and daily discoveries about its structure and function.These questions cannot be answered in a vacuum.Issues surrounding resource allocation, for example, are informed not only by the view of clinicians who administer the treatment and assess patients in follow-up but also by industry that markets and sells the technology, and allied health providers and patients who experience and need the interventions themselves.It is challenging, if not impossible to capture or understand the implications of a new device, for example, without viewing it in these various contexts.Similarly, decisions in the clinical neuromodulation world are rarely made in isolation.For example, despite robust evidence for the efficacy of deep brain stimulation (DBS) for Parkinson's disease, where the procedure is standard of care, the decision to proceed with surgery is not the surgeon's alone.Every case is conferenced with a team consisting of neurologist, neuropsychologist,

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.011
metaresearch head score (Gemma)0.015
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesScience and technology studies
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.987
Threshold uncertainty score0.950

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0110.015
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0030.004
Science and technology studies0.0130.008
Scholarly communication0.0110.004
Open science0.0020.005
Research integrity0.0040.007
Insufficient payload (model declined to judge)0.0160.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.094
GPT teacher head0.313
Teacher spread0.219 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes4
Has abstractyes

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