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Record W4377138740 · doi:10.1002/pds.5639

Differences in target estimands between different propensity score‐based weights

2023· article· en· W4377138740 on OpenAlexafffund
Peter C. Austin

Bibliographic record

VenuePharmacoepidemiology and Drug Safety · 2023
Typearticle
Languageen
FieldMathematics
TopicAdvanced Causal Inference Techniques
Canadian institutionsInstitute for Clinical Evaluative SciencesSunnybrook HospitalUniversity of Toronto
FundersCanadian Institutes of Health ResearchOntario Ministry of Health and Long-Term Care
KeywordsPropensity score matchingWeightingStatisticAverage treatment effectStatisticsMathematicsMatching (statistics)Observational studyInverse probability weightingMedicine

Abstract

fetched live from OpenAlex

PURPOSE: Propensity score weighting is a popular approach for estimating treatment effects using observational data. Different sets of propensity score-based weights have been proposed, including inverse probability of treatment weights whose target estimand is the average treatment effect, weights whose target estimand is the average treatment effect in the treated (ATT), and, more recently, matching weights, overlap weights, and entropy weights. These latter three sets of weights focus on estimating the effect of treatment in those subjects for whom there is clinical equipoise. We conducted a series of simulations to explore differences in the value of the target estimands for these five sets of weights when the difference in means is the measure of treatment effect. METHODS: We considered 648 scenarios defined by different values of the prevalence of treatment, the c-statistic of the propensity score model, the correlation between the linear predictors for treatment selection and the outcome, and by the magnitude of the interaction between treatment status and the linear predictor for the outcome in the absence of treatment. RESULTS: We found that, when the prevalence of treatment was low or high and the c-statistic of the propensity score model was moderate to high, that matching weights, overlap weights, and entropy weights had target estimands that differed meaningfully from the target estimand of the ATE weights. CONCLUSIONS: Researchers using matching weights, overlap weights, and entropy weights should not assume that the estimated treatment effect is comparable to the ATE.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.429
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.283
GPT teacher head0.432
Teacher spread0.149 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations23
Published2023
Admission routes2
Has abstractyes

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