(305) Impact of Melatonin Supplementation on Testosterone Levels in U.S. Adult Men
Bibliographic record
Abstract
Abstract Introduction Among US adults, the prevalence of melatonin supplement consumption significantly increased in the last two decades across all demographic groups. Despite scant evidence, melatonin is widely used as an over-the-counter sleep aid. Because sleep disorders are associated with testosterone deficiency, we examined the associati.n between melatonin supplementation and serum testosterone levels. Objective Evaluate the association between melatonin supplementation and serum testosterone levels in adult males living in the United States. Methods The National Health and Nutrition Examination Survey (NHANES) was used to analyze interviews, physical examinations, and laboratory tests. Data from three cycles (2011-2012, 2013-2014, and 2015-2016) was combined (appended) to study the association between melatonin usage and early morning serum total testosterone (TT) levels. Selection criteria included men aged 18 and older; exclusion criteria included the reported use of testosterone, clomiphene, or anastrozole medications or supplements in the past 30 days. Additionally, participants with missing values for age, body mass index (BMI), sleep habits, or EMSTT were excluded from the analysis. Statistical analysis was performed using SPSS v.28. Continuous variables were presented as medians and interquartile ranges [25 - 75]. To determine the association between of low EMSTT (T < 300 ng/dL = low) and clinical variables, demographics characteristics, a multivariable-adjusted logistic regression analysis was performed. Results After selection, 7,656 participants were analyzed, of those, the median age was 47 [31 - 63] years old, the median TT level was 389.9 [289 - 513.9] ng/dL, and 27.4% of participants were found to have low TT, and 51 (0.7%) reported melatonin supplementation. Among individuals who reported melatonin intake in the past 30 days, the average intake was approximately 1 mg/day. On multivariable adjusted analysis increase age (OR = 1.019, p < 0.001), and BMI (OR = 1.133, p < 0.001) were associated with increased risk of low TT. However, we did not find an association with low testosterone among men who reported melatonin supplementation (p=0.898) even after analyzing for confounding variables. Conclusions These findings suggest that melatonin supplementation within the past 30 days was not associated with low TT levels in a nationally representative sample of men aged 18 and older. Further analyses are needed to highlight the dose-response relationship and examine the potential effects of exposure to supratherapeutic doses and chronic intake. Disclosure No
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".