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Record W4378469682 · doi:10.3389/fevo.2023.1156853

Risky business: relating probability of direct contact to risk of chronic wasting disease

2023· article· en· W4378469682 on OpenAlexafffundabout
Maria Dobbin, Peter Smolko, Laurens Put, Evelyn H. Merrill

Bibliographic record

VenueFrontiers in Ecology and Evolution · 2023
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicPrion Diseases and Protein Misfolding
Canadian institutionsUniversity of Alberta
FundersNatural Sciences and Engineering Research Council of CanadaRocky Mountain Elk FoundationUniversity of AlbertaGovernment of AlbertaAlberta Conservation Association
KeywordsChronic wasting diseaseOdocoileusOutbreakGeographyEcologyDemographyWildlife diseaseBiologyDiseaseWildlifeMedicinePrion proteinVirology

Abstract

fetched live from OpenAlex

Chronic wasting disease (CWD) is a fatal, prion disease of cervids that was first detected in Alberta in 2005. Transmission of CWD by direct contact with infected individuals plays a major role in the early phases of an outbreak. Mule deer ( Odocoileus hemionus ) comprise 85% of CWD-infected animals in the province, and we investigated the seasonal effects of grouping patterns and landscape heterogeneity on direct, pair-wise contacts (distance of 3 m) within and between sex-specific (same or mixed sex) groups of mule deer in east-central Alberta. We determined seasonal contacts of mule deer based on proximity loggers that alter GPS schedules to record contact locations. We modeled the relative risk of contact between sex-specific dyads both within and between social groups based on landscape characteristics at the location of contact. We then assessed the support for 5 hypotheses that linked locations of seasonal contacts to occurrence of CWD on the landscape. Disease occurrence on the landscape was derived by comparing locations of CWD-infected and CWD-uninfected deer collected as part of the Alberta’s CWD hunter-harvest surveillance program. We found that contacts in winter occurred in areas where deer use was concentrated, whereas in summer, contact locations were less constrained in space where patterns of landscape characteristics at contact locations varied between sex-specific dyads. Contact probabilities of within and between-group male dyads in winter and between-group female dyads in summer were the best predictors of CWD risk in east-central Alberta. Our results relate habitat specific, social behaviors between conspecific mule deer to potential routes of CWD transmission and contribute to CWD research that guides management strategies for an emergent wildlife disease.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.016
Threshold uncertainty score0.322

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.219
Teacher spread0.214 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2023
Admission routes3
Has abstractyes

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