Diversity, Transmission and Selective Pressure on the Proteome of <i>Pseudomonas aeruginosa</i>
Bibliographic record
Abstract
Pseudomonas aeruginosa is often described as a ubiquitous species in the natural environment, in addition to its role as an opportunistic pathogen to both humans and animals. Strains isolated from clinical and natural environments reveal extensive diversity in the characteristics of P. aeruginosa and this chapter explores the relationship between phenotypes and the proteome. We explore the potential selective pressures on the proteome that arise from the diverse lifestyles of P. aeruginosa and the capacity of mass spectrometry techniques to capture such proteomic changes. A comparative proteogenomic analysis also examines the potential proteomic adaptive process, which varies between two clonal lineages, and we highlight unique genomic and proteomic markers that may divide these clades. Collectively, this chapter discusses the role of such proteomic changes in P. aeruginosa transmission processes, which are becoming increasingly important to understand as the species presents with further antibiotic resistances across all of its sources.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".