Clinical effectiveness and tolerability of UC-II, sodium hyaluronate, and curcumin in osteoarthritis of the knee – CAPE Study: A multicentre, Prospective, real-world evidence study
Bibliographic record
Abstract
Background: Osteoarthritis (OA) is a degenerative joint disease that results in the breakdown of cartilage, causing pain, stiffness, and decreased range of motion in the affected joints. It is a common form of arthritis, particularly in older adults. Undenatured type II collagen (UC-II) is a nutritional supplement which has been found to be effective in treating OA.Objective: To determine the efficacy and safety of UC-II, sodium hyaluronate, and curcumin in treating knee OA.Materials and Methods: 813 patients with knee OA were enrolled in the study. Subjects received a capsule containing 40 mg UC-II, 80 mg sodium hyaluronate and 200 mg curcumin once daily for three months. The Western Ontario and McMaster Osteoarthritis Index (WOMAC) evaluated pain, joint stiffness, and physical functions. A Visual Analog Scale (VAS) was used to assess the severity of the initial pain. Moreover, clinical symptom scores and patient and physician global assessments were evaluated. The patients were assessed before the treatment and three months after the initiation of the treatment. Results: The WOMAC scores for pain, stiffness, and function, as well as the VAS score, were significantly improved (P< 0.05) in subjects after three months compared to the baseline. There was a 73.51% improvement in the total WOMAC scores and a 69.92% improvement in the VAS scores. There was a significant reduction in clinical symptoms, and global assessments of treatment by patients and physicians based on overall efficacy were favourable after the three-month treatment.Conclusion: The study showed that UC-II, sodium hyaluronate and curcumin in combination effectively improve the symptoms of OA and should be positively considered for the symptomatic management of OA.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".