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Record W4379094559 · doi:10.1053/j.gastro.2023.05.032

Gut Microbiome Composition Is Associated With Future Onset of Crohn’s Disease in Healthy First-Degree Relatives

2023· article· en· W4379094559 on OpenAlexafffund
Juan A. Raygoza Garay, Williams Turpin, Sun-Ho Lee, Michelle I. Smith, Ashleigh Goethel, Anne M. Griffiths, Osvaldo Espin‐Garcia, Maria Abreu, Guy Aumais, Çharles N. Bernstein, I Avni Biron, Maria Cino, Colette Deslandres, Iris Dotan, Brian G. Feagan, David S. Guttman, Hien Q. Huynh, Jeffrey S. Hyams, Kevan Jacobson, John K. Marshall, Anthony Otley, Remo Panaccione, Mark J. Ropeleski, Mark S. Silverberg, A. Hillary Steinhart, Baruch Yerushalmi, Andrew D. Paterson, Wei Xu, Paul L. Beck, Kenneth Croitoru, Gilaad G. Kaplan, Denis O. Krause, Karen Madsen, Ernest G. Seidman, Scott B. Snapper, Andy Stadnyk, Hillary Steinhart, Michael G. Surette, Tom Walters, Bruce A. Vallance, Alain Bitton, Jeff Critch, Lee A. Denson, C Deslandres, Hans Herfarth, Peter Higgins, Jerry McGrath, Remo Panancionne

Bibliographic record

VenueGastroenterology · 2023
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGut microbiota and health
Canadian institutionsSinai Health SystemQueen's UniversityUniversity of OttawaBC Children's HospitalUniversity of AlbertaIzaak Walton Killam Health CentreHôpital Maisonneuve-RosemontUniversity of ManitobaUniversity of CalgaryMount Sinai HospitalPrincess Margaret Cancer CentrePublic Health OntarioHospital for Sick ChildrenDalhousie UniversityCentre Hospitalier Universitaire Sainte-JustineMcMaster UniversityChildren's Hospital of Eastern OntarioPopulation Health Research InstituteUniversity Health NetworkWestern UniversityUniversity of Toronto
FundersCrohn's and Colitis CanadaFerring PharmaceuticalsCanada Research ChairsCanadian Association of GastroenterologyNational GEM ConsortiumCanadian Institutes of Health ResearchLeona M. and Harry B. Helmsley Charitable Trust
KeywordsMicrobiomeRoseburiaCohortMetagenomicsGut floraDiseaseRuminococcusBiologyCrohn's diseaseImmunologyInflammatory bowel diseaseMedicineInternal medicineBioinformaticsGeneticsLactobacillusBacteriaGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.014

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0010.000
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0040.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.251
Teacher spread0.239 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations192
Published2023
Admission routes2
Has abstractno

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