P305 The impact of bowel urgency on the lives of patients with ulcerative colitis in the US and Europe: CONFIDE survey
Bibliographic record
Abstract
Background Communicating Needs and Features of IBD Experiences (CONFIDE) aims to increase understanding of impact of symptoms on patients with moderate-severe ulcerative colitis (UC) and Crohn’s disease in US, Europe (EUR), and Japan. These data focus on patients in US and EUR. Methods Online, quantitative, cross-sectional surveys of moderate-severe UC patients were conducted in US and EUR (France, Germany, Italy, Spain, and UK). Data included patient perspectives on their UC symptoms and the impact on their daily lives. Results A total of 200 US patients (62% male, mean age 40.4 years) and 556 EUR patients (57% male, mean age 38.9 years) completed the survey, with 77% and 54% currently receiving advanced therapies (biologic or novel oral therapy), respectively. The top 3 symptoms currently experienced by US and EUR patients were diarrhoea (63% and 50%), bowel urgency (47% and 30%) and increased stool frequency (39% and 30%). Among patients who have ever experienced bowel urgency, 93% of US and 89% of EUR patients reported doing so at least once a month over the past 3 months. Among patients who have ever experienced urge incontinence (bowel urgency-related accidents), 86% of US and 71% of EUR patients reported doing so at least once a month over the past 3 months. 69% and 65% of all US and EUR patients with UC, respectively, reported wearing a diaper/pad/protection at least once a month in the past 3 months due to fear/anticipation of urge incontinence. For patients receiving advanced therapies, similar patterns were observed for frequency of bowel urgency and urge incontinence and wearing diaper/pad/protection due to fear/anticipation of urge incontinence. Among both US and EUR patients, the most common UC-related reasons for declining participation in social events were bowel urgency (43% and 30%) and fear of urge incontinence (40% and 32%). Similarly, the most common reasons for declining participation in work/school and sports/physical exercise were bowel urgency and fear of urge incontinence. Conclusion Bowel urgency, which was the second-most frequently reported symptom, has an extensive impact on the lives of patients with moderate to severe UC. In this younger patient population, including patients receiving advanced therapies, almost two thirds of US and EUR patients reported wearing diapers/pads/protection at least once a month in the past 3 months due to fear/anticipation of urge incontinence. Even if patients were not currently experiencing bowel urgency, the persistent impact of UC was demonstrated by the use of diaper/pads/protection.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.006 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".