Ophthalmic evaluation in patients after simultaneous pancreas-kidney transplantation (SPK) due to complications of type 1 diabetes mellitus, and in type 1 diabetic patients assessed for eligibility for SPK
Bibliographic record
Abstract
streszczenie Aim: Ophthalmic evaluation of patients after simultaneous pancreas-kidney transplantation (SPK) due to complications of type 1 diabetes mellitus, and type 1 diabetic patients assessed for eligibility for SPK. Material and methods:We performed an ophthalmic evaluation in 37 patients after SPK and 49 patients assessed for eligibility for SPK in the Central Clinical Hospital of the Ministry of Interior in Warsaw between January 2016 and March 2020.Ophthalmic evaluation included measurements of best corrected visual acuity, anterior and posterior eye segment examinations, fundus digital photography, and OCT.Results: In the patients after SPK, we found a statistically significant correlation between atrophy in the photoreceptor inner segment/outer segment junction (IS/OS line) on OCT and the pre-transplant HbA1 level.In the group of patients evaluated before and within one year after SPK, we confirmed activa-tion of retinopathy in 66.7% of examined eyes.OCT performed during the assessment of eligibility for SPK revealed atrophy in the IS/OS line in 47% of examined eyes.Conclusions: Changes in the retina associated with poor pretransplant diabetes control determine the best achievable visual acuity even after long-term normalization of glycemia following SPK.Patients after SPK require frequent comprehensive ophthalmological follow-up examinations during the first year after transplantation because of the risk of diabetic retinopathy progression.Despite the limitations resulting from their baseline status, more than half of all patients after SPK (51%) have a visual acuity of > 0.6 at least in one eye, which is sufficient for independent functioning.Patients eligible for SPK exhibit macular changes on OCT, hypoperfusion on angio-OCT, and 47% atrophy in the IS/OS line.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".