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Record W4382542421 · doi:10.1016/j.str.2023.06.002

Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40

2023· article· en· W4382542421 on OpenAlex
Matthew G. Alteen, Justin C. Deme, Claudia Alvarez, P. Loppnau, Ashley Hutchinson, Alma Seitova, Renu Chandrasekaran, Eduardo Silva Ramos, Christopher Secker, Mona Alqazzaz, Erich E. Wanker, Susan M. Lea, C.H. Arrowsmith, Rachel Harding

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueStructure · 2023
Typearticle
Languageen
FieldNeuroscience
TopicGenetic Neurodegenerative Diseases
Canadian institutionsPrincess Margaret Cancer CentreSciex (Canada)Structural Genomics ConsortiumUniversity of Toronto
FundersJanssen CanadaGenentechInnovative Medicines InitiativeOntario Genomics InstituteNational Institutes of HealthOntario GenomicsMerck KGaAGenome CanadaCHDI FoundationBayerPfizerEuropean Federation of Pharmaceutical Industries and AssociationsTakeda Pharmaceutical CompanyBristol-Myers SquibbInnovative Health InitiativeMcGill UniversityBoehringer IngelheimMassachusetts General HospitalHuntington's Disease Society of America
KeywordsHuntingtinProtein–protein interactionComputational biologyScaffold proteinFunction (biology)BiologyProtein functionChemistryCell biologyBiochemistrySignal transductionGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.050
Threshold uncertainty score0.215

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.023
GPT teacher head0.241
Teacher spread0.219 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it