COMPARAÇÃO DE DOIS SISTEMAS MATRIX-ASSISTED LASER DESORPTION IONIZATION - TIME OF FLIGHT / MASS SPECTROMETRY PARA IDENTIFICAÇÃO DE BACTÉRIAS ISOLADAS DE UMA INDÚSTRIA PRODUTORA DE IMUNOBIOLÓGICOS DO RIO DE JANEIRO
Bibliographic record
Abstract
INTRODUO:A identificao de microrganismos isolados no controle microbiolgico de produo farmacutica fornece informaes importantes para rastrear as fontes de contaminao, implementar aes corretivas adequadas, e compreender a composio da microbiota.A utilizao de mtodos de identificao rpidos e eficazes pode evitar o descarte de lotes sem necessidade ou liberao de produtos sem qualidade.Estudos utilizando a metodologia Matrix-Assisted Laser Desorption Ionization -Time of Flight / Mass Spectrometry (MALDI-TOF/MS) amostram-se como uma boa opo para a identificao de linhagens isoladas em indstrias, pela rapidez e pela acurcia dos resultados.A tcnica MALDI-TOF/MS rpida, mostra uma elevada especificidade e uma excelente sensibilidade.OBJETIVOS: O objetivo deste estudo foi comparar dois sistemas MALDI-TOF/MS na identificao de linhagens bacterianas isoladas a partir de uma indstria farmacutica produtora de imunobiolgicos localizada no Rio de Janeiro/RJ.METODOLOGIA: Foram utilizadas 63 linhagens isoladas no perodo de 2010 a 2021, cultivadas em gar Triptona de Soja, que foram analisadas nos equipamentos MALDI Biotyper (Bruker) e VITEK MS (bioMrieux), de acordo com
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".