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Record W4383263330 · doi:10.55927/ijis.v2i6.4392

Evolutionary Biology and Drug Development

2023· article· en· W4383263330 on OpenAlexfundno aff
Rehan Haider

Bibliographic record

VenueInternational Journal of Integrative Sciences · 2023
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicEvolution and Genetic Dynamics
Canadian institutionsnot available
FundersUniversity of KarachiUniversity of Calgary
KeywordsData scienceResistance (ecology)Resource (disambiguation)Subject (documents)Computer scienceBiologyWorld Wide WebEcology

Abstract

fetched live from OpenAlex

Evolution is the unifying framework in biology and scales to all dwelling systems. It is the central organizing questioning to grant clarification for reputedly disparate herbal phenomena; from the very small (individual molecules) to the very large (ecosystems), from the upward push and unfold of molecular editions to the habits and physique shapes of elephants. In modern times, our maintain shut for evolution in medicinal pills has acquired momentum. Individuals have championed the cause, dedicated journals have emerged, and new books on the trouble are often posted (“The Evolution and Medicine Review” is an terrific web-based advisable useful resource presenting up to date information on the subject, http://evmedreview.com). This union between evolution and cure has already most fulfilled our hold close of pathological techniques (Maccallum, 2007, Nesse & Stearns, 2008). Drug enchancment and therapeutic strategies are areas in which evolutionary standards would perchance moreover be specially helpful. The avalanche of bioinformatic methods, genomic data, and the subsequent emergence of evolutionary genomics in the ultimate few many years propose that integrating these fields into drug graphs is now a possibility. Incorporating evolutionary documents is now not completely really useful a posteriori when we might also moreover in addition hope to apprehend why resistance to a special compound emerged. It is in addition treasured a priori, to structure increased efficacious drugs, suggest possible resistance profiles and conceptualize novel therapeutic strategies

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.459
Threshold uncertainty score0.172

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.329
Teacher spread0.317 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

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