MétaCan
Menu
Back to cohort
Record W4383746430 · doi:10.1016/s2468-1253(23)00148-6

Efficacy and safety of the siRNA JNJ-73763989 and the capsid assembly modulator JNJ-56136379 (bersacapavir) with nucleos(t)ide analogues for the treatment of chronic hepatitis B virus infection (REEF-1): a multicentre, double-blind, active-controlled, randomised, phase 2b trial

2023· article· en· W4383746430 on OpenAlexaff
Man‐Fung Yuen, Tarik Asselah, Ira M. Jacobson, Maurizia Rossana Brunetto, Harry L.A. Janssen, Tetsuo Takehara, Jin Hou, Thomas N. Kakuda, Tom Lambrecht, Maria Beumont, Ronald Kalmeijer, Carine Guinard‐Azadian, Cristiana Mayer, John Jezorwski, Thierry Verbinnen, Oliver Lenz, Umesh Shukla, Michael Biermer, Stefan Bourgeois, Thomas Vanwolleghem, Frederik Nevens, Yves Horsmans, Hans Van Vlierberghe, Ana Catharina de Seixas Santos Nastri, Marcus Lacerda, Alnoor Ramji, Brian Conway, Carla S. Coffin, Scott Fung, Stephen D. Shafran, Jan Šperl, Petr Urbánek, Stanislav Plíšek, Václav Hejda, Didier Samuel, Karine Lacombe, Fabien Zoulim, Dominique Guyader, F. Raffi, Marc Bourlière, Marie‐Noëlle Hilleret, Heiner Wedemeyer, Julian Schulze zur Wiesch, Kathrin Sprinzl, Gudrun Hilgard, Michael Sabranski, Keikawus Arastéh, Henry LY Chan, Vincent Wai‐Sun Wong, Gloria Taliani, Pietro Andreoné, Pietro Lampertico, Masayuki Kurosaki, Hiroshi Yatsuhashi, Kei Fujiwara, Tomokazu Kawaoka, Yasuhiro Asahina, Hirayuki Enomoto, Kazuhisa Yabushita, Kazuo Notsumata, Koichi Takaguchi, Naoto Kawabe, Naoya Kato, Tadashi Namisaki, Yoshiyuki Suzuki, Jung‐Hwan Yoon, Sang Hoon Ahn, Young‐Suk Lim, Seung Woon Paik, Kuang Kiat Kiew, Rosmawati Mohamed, Soek Siam Tan, Yeong Yeh Lee, Maria Hlebowicz, Hanna Berak, Jacek Gąsiorowski, Waldemar Halota, Ewa Janczewska, Natalia Geyvandova, Viacheslav Morozov, А. А. Андреева, Д. А. Гусев, E. I. Bessonova, М. Ф. Осипенко, Svetlana Romanova, Natalia Gankina, Olga Sagalova, Tatiana Stepanova, M. Diago, Fernandez Inmaculada, José Luís Calleja, Xavier Forns, Marı́a Buti, Pisit Tangkijvanich, Tawesak Tanwandee, Teerha Piratvisuth, Apinya Leerapun, Gürdal Yılmaz, Ulus Salih Akarca, Murat Akova, Ramazan Idılman, Daniel Forton, David Bell, Kosh Agarwal, Patrick Kennedy, Franco Felizarta, Mark Sulkowski, Ronald Nahass, Sergio Rojter, Kevin Korenblat, Norman Gitlin

Bibliographic record

Venue˜The œLancet. Gastroenterology & hepatology · 2023
Typearticle
Languageen
FieldMedicine
TopicHepatitis B Virus Studies
Canadian institutionsUniversity Health Network
FundersJanssen Research and DevelopmentGilead SciencesGlaxoSmithKlineEisaiArrowhead PharmaceuticalsFujirebio USBristol-Myers Squibb
KeywordsMedicineHepatitis B virusHBeAgHepatitis BInternal medicinePegylated interferonHBsAgGastroenterologyVirologyChronic hepatitisVirus

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.007
Threshold uncertainty score0.023

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.001
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0030.002
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0010.000
Research integrity0.0020.003
Insufficient payload (model declined to judge)0.0070.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.033
GPT teacher head0.310
Teacher spread0.277 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations76
Published2023
Admission routes1
Has abstractno

Explore more

Same venue˜The œLancet. Gastroenterology & hepatologySame topicHepatitis B Virus StudiesFrench-language works237,207