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Record W4383873232 · doi:10.1007/s10549-023-06991-3

Tamoxifen and the risk of breast cancer in women with a BRCA1 or BRCA2 mutation

2023· article· en· W4383873232 on OpenAlexafffund
Joanne Kotsopoulos, Jacek Gronwald, Tomasz Huzarski, Amber M. Aeilts, Susan Randall Armel, Beth Y. Karlan, Christian F. Singer, Andrea Eisen, Nadine Tung, Olufunmilayo I. Olopade, Louise Bordeleau, Charis Eng, William D. Foulkes, Susan L. Neuhausen, Carey A. Cullinane, Tuya Pal, Robert Fruscio, Jan Lubiński, Kelly Metcalfe, Ping Sun, Steven A. Narod, Georgia L. Wiesner, Aletta Poll, Raymond H. Kim, Jeanna McCuaig, Dana Zakalik, Fergus J. Couch, Linda Steele, Howard M. Saal, Edmond G. Lemire, Kim Serfas, Kevin Sweet, Seema Panchal, Christine Elser, Robert E. Reilly, Joanne L. Blum, Cezary Cybulski, Daniel Rayson, Teresa Ramón, J.S. Dungan, Stefania Zovato, Antonella Rastelli, Pål Møller, Stephanie A. Cohen

Bibliographic record

VenueBreast Cancer Research and Treatment · 2023
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicBRCA gene mutations in cancer
Canadian institutionsMcGill UniversityJuravinski Cancer CentreSunnybrook Health Science CentrePrincess Margaret Cancer CentrePublic Health OntarioMcMaster UniversityWomen's College HospitalUniversity of Toronto
FundersCanadian Institutes of Health ResearchPeter Gilgan FoundationCanada Research ChairsCanadian Cancer Society
KeywordsBreast cancerTamoxifenMedicineOncologyInternal medicineGynecologyBRCA2 ProteinAntiestrogenMutationCancerGermline mutationBiologyGeneticsGene

Abstract

fetched live from OpenAlex

OpenAlex records an abstract for this work, but it could not be fetched just now.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.007

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.022
GPT teacher head0.338
Teacher spread0.316 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations22
Published2023
Admission routes2
Has abstractyes

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