KNEE REPLACEMENT RISK PREDICTION MODELING fOR KNEE OSTEOARTHRITIS USING CLINICAL AND MAGNETIC RESONANCE IMAGE FEATURES: DATA FROM THE OSTEOARTHRITIS INITIATIVE
Classification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
This study aims to develop effective predictive models to assess knee replacement (KR) risk in knee osteoarthritis (KOA) patients, which is important in the personalized diagnosis, assessment, and treatment of KOA. A total of 269[Formula: see text]KOA patients were selected from the osteoarthritis initiative (OAI) public database and their clinical and knee cartilage image feature data were included in this study. First, the clinical risk factors were screened using univariate Cox regression and then used in the construction of the Clinical model. Next, their image features were selected using univariate and least absolute shrinkage and selection operator (LASSO) Cox methods step by step, and then used in the construction of the Image model. Finally, the Image+Clinical model was constructed by combining the Image model and clinical risk factors, which was then converted into a nomogram for better visualization and future clinical use. All models were validated and compared using the metric of C-index. In addition, Kaplan–Meier (KM) survival curve with log-rank test and calibration curve were also included in the assessment of the model risk stratification ability and prediction consistency. Age and three Western Ontario and McMaster Universities (WOMAC) scores were found significantly correlated with KR, and thus included in Clinical model construction. Fifty-eight features were selected from 92[Formula: see text]knee cartilage image features using univariate cox, and four image features were retained using the LASSO Cox method. Image+Clinical model and nomogram were finally constructed by combining clinical risk factors and the Image model. Among all models, the Image+Clinical model showed the best predictive performance, and the Image model was better than the Clinical model in the KR risk predictive consistency. By determining an optimal cutoff value, both Image and Image+Clinical models could effectively stratify the KOA patients into KR high-risk and low-risk groups (log-rank test: [Formula: see text]). In addition, the calibration curves also showed that model predictions were in excellent agreement with the actual observations for both 3-year and 6-year KR risk probabilities, both in training and test sets. The constructed model and nomogram showed excellent risk stratification and prediction ability, which can be used as a useful tool to evaluate the progress and prognosis of KOA patients individually, and guide the clinical decision-making of KOA treatment and prognosis.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it