Dissecting the cell of origin of aberrant SALL4 expression in myelodysplastic syndrome
Bibliographic record
Abstract
Dear Editor,Despite the increased reports on oncofetal protein Spalt like transcription factor 4 (SALL4) in myelodysplastic syndrome (MDS), the cellular identity of its aberrant expression in MDS patients remains unknown.Uncovering the answer to this question has important implications for furthering our understanding of the pathogenesis of F I G U R E 1 SALL4 RNA and protein were expressed in MDS bone marrow cells.(A) SALL4 expression in MDS CD34 positive cells from the public database GSE19429.(B) SALL4 expression in CD34 positive cells in MDS subtype from the public database GSE19429.RA, refractory anemia; RARS, refractory anemia with ring sideroblasts; RAEB1, refractory anemia with excess blasts1; RAEB2, refractory anemia with ring sideroblasts2.(C) MMI of SALL4 in bone marrow cells on CyTOF (MDS patients, n = 10, control BM, n = 5, error bars indicate standard deviation).Data analysis used Mann-Whitney U test.*p ≤ .05;**p ≤ .01. ns, not significant; HSPC, hematopoietic stem and progenitor cell; HSC, Hematopoietic stem cell; HPC, hematopoietic progenitor cell; MPP, multipotent progenitors, CMP; common myeloid progenitor; GMP granulocyte-monocyte progenitor; MEP, megakaryocyte-erythrocyte progenitor; NK cell, natural killer cell; MMI, median metal intensity.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.003 |
| Insufficient payload (model declined to judge) | 0.003 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".