Prognostic Scoring and Outcome of Gestational Trophoblastic Disease Patients
Bibliographic record
Abstract
Background: Gestational trophoblastic neoplasia (GTN) uses prognostic scores to predict the development of resistance to single-agent chemotherapy. Requiring combination chemotherapy, high-risk patients are defined as those with an International Federation of Gynecology and Obstetrics (FIGO) score ≥ 7. Treatment at a specialized center based on an appropriate and prompt diagnosis is needed for the reduction of untimely death as well as to improve the survivability of patients. This study aimed to study for classifying definitions of low-risk, high-risk, and ultra-high-risk prognostic scores. Also, the outcomes of gestational trophoblastic patients and brain metastasis have been observed. Methods: The study was observational design. The medical records of 56 gestational trophoblastic patients who visited the Buddhachinaraj Phitsanulok Hospital between 2012 and 2022 were collected and reviewed. The patients had been classified into three groups: low-risk, high-risk, and ultra-high-risk. The low-risk was stage I - III with a score < 7, while the high-risk was defined as FIGO stage II-III with a score ≥ 7. Also, a risk score ≥ 13 was defined as ultra-high risk. Results: Among the 56 patients in this study, 47 patients were at low-risk, accounting for 83.9%, while nine patients were at high-risk (16.1%). No patient had a score of more than 12, defined as ultra-high-risk. All patients had been alive for at least 10 years after diagnosis with brain metastasis stage IV. The incidence of high-risk GTN patients was displayed in 9/56 (16.1%) with lung and brain metastasis. The high-risk score of GTN with brain metastasis showed an incidence rate of GTN patients among 1/56 (1.78%). The ultra-high-risk group was not presented. Conclusions: Multimodality treatment has benefits for stage IV patients and high-risk groups. However, ultra-high-risk patients with a prognostic score higher than 12 or ≥ 13 have slightly increased mortality rates. A high-risk group FIGO stage IV with brain metastasis is alive in this study. J Clin Gynecol Obstet. 2023;12(2):46-51 doi: https://doi.org/10.14740/jcgo876
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.103 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".