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PB2064: THE COMPLETE STUDY: A SINGLE ARM, MULTICENTER OBSERVATIONAL STUDY TO EVALUATE EFFECTIVENESS OF PEGCETACOPLAN UNDER REAL WORLD CONDITIONS IN PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)

2023· article· en· W4385655000 on OpenAlexaboutno aff
Régis Peffault de Latour, Jeff Szer, Austin Kulasekararaj, Anna Gayà, Simona Sica, Matthias Nölte, Regina Horneff, L Stefan

Bibliographic record

VenueHemaSphere · 2023
Typearticle
Languageen
FieldImmunology and Microbiology
TopicComplement system in diseases
Canadian institutionsnot available
Fundersnot available
KeywordsParoxysmal nocturnal hemoglobinuriaEculizumabMedicineAnemiaObservational studyInternal medicineHemolysisHemoglobinuriaPediatricsIntensive care medicineComplement systemImmunologyAntibody

Abstract

fetched live from OpenAlex

Topic: 12. Bone marrow failure syndromes incl. PNH - Clinical Background: Paroxysmal nocturnal hemoglobinuria (PNH) is caused by complement-mediated hemolysis with resultant thrombosis risk and a substantial patient symptom burden. Complement C5 inhibitors (C5i) have improved outcomes by reducing intravascular hemolysis (IVH). Extravascular hemolysis (EVH) continues or becomes evident under C5i treatment, with anemia persisting or recurring in >80% of patients, which may lead to transfusion dependence, fatigue, and impaired quality of life (QoL) (Risitano et al. Blood 2009; Panse et al. Eur J Haematol 2022). Pegcetacoplan is a novel complement C3 inhibitor (C3i) that controls EVH and IVH. In the phase 3 PEGASUS (NCT03500549) trial of patients with persistent anemia despite eculizumab therapy, pegcetacoplan showed head-to-head superiority in mean hemoglobin (Hb) change vs. eculizumab. Pegcetacoplan also demonstrated rapid and sustained Hb stabilization in complement inhibitor-naïve patients in the phase 3 PRINCE (NCT04085601) trial. Pegcetacoplan was approved by the EMA in 2021 for adult PNH patients who are anemic after C5i treatment for ≥3 months. There is currently a need for real-world data on pegcetacoplan usage and effectiveness in the PNH community. Aims: To describe real-world effectiveness of pegcetacoplan in the treatment of adult patients with PNH (Figure 1). QoL and health care resource use, physician and patient satisfaction with the treatment will also be assessed. Methods: COMPLETE is a Phase 4, multicenter, observational study aiming for 200 patients across 70 sites in Europe, the Middle East, Canada, and Australia. The study will include patients (≥18 years) with documented PNH diagnosis who started pegcetacoplan ≤12 months prior enrollment or are prescribed pegcetacoplan at enrollment. The decision to start treatment will be made by the treating physician and independent from the decision to include the patient in the study. Patients who initiated current pegcetacoplan treatment in an interventional trial, those enrolled in a concurrent interventional study or receiving an investigational product ≤3 months prior to start of current pegcetacoplan treatment, will be excluded. The primary endpoint is change in observed Hb level from initiation of pegcetacoplan treatment to 6 months. Changes in lactate dehydrogenase, absolute reticulocyte count, bilirubin, haptoglobin, and ferritin levels will also be assessed from treatment initiation to 6 months. These parameters will be determined at 6-month intervals until the end of study. The alleviation of ongoing anemia will be evaluated by assessing the achievement of Hb ≥12 g/dL and increase in Hb of ≥2 g/dL, likewise at 6-month intervals. Lastly, endpoints reflective of acute events will be examined, including annualized number and units of red blood cell transfusions and acute hemolytic events requiring additional intervention. Adverse events will be collected throughout the study. QoL will be evaluated via patient reported outcome scores. Healthcare resource use will be assessed by number of hospitalizations and emergency room visits. Physician and patient satisfaction with the treatment will also be determined. The total planned study duration is 48 months, with the main part being prospective, and retrospective data being collected for ≤12 months prior to start of pegcetacoplan. Results: Enrollment is expected to begin in Q3 2023 with the final report anticipated in Q1 2028. Summary/Conclusion: Pegcetacoplan is a newly approved, novel PNH therapy. This study aims to describe real-world usage and effectiveness of pegcetacoplan in PNH patients.Keywords: Paroxysmal nocturnal hemoglobinuria (PNH), Quality of life, Complement, Real world data

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.007
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.075
GPT teacher head0.328
Teacher spread0.253 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2023
Admission routes1
Has abstractyes

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