p(thyme oil) and p(clove oil) organo‐particles with biocompatible, anticancer, antioxidant, and antibacterial properties against Capan‐1 and L‐929 cells
Bibliographic record
Abstract
Abstract The synthesis of p(ClO) and p(TO) organo‐particles from clove oil and thyme oil is the first in the literature. The particles were tested against the L‐929 cell line for cell viability/cytotoxicity. The anticancer activity was studied against the Capan‐1 pancreatic cancer cell line. p(ClO) and p(TO) organo‐particles were featured by thermogravimetry (TGA), Fourier transform infrared spectroscopy (FT‐IR), scanning electron microscopy (SEM), particle size (DLS), and particle charge (zeta potential, Zeta) analyses. Antioxidant, biocompatible, antimicrobial, and in vitro cytotoxicity specialties were investigated. p(ClO) and p(TO) organo‐particles were found to be effective on the L‐929 fibroblast cell line and Capan‐1 pancreatic cancer cell line in research on Capan‐1 and L‐929 cell lines. Additionally, it was shown that large dosages of p(ClO) organo‐particles were not hazardous to L‐929 cell lines. A difference was found between the rates of cell viability and apoptosis and necrosis when the MTT study findings of p(ClO) and p(TO) organo‐particles were studied in Capan‐1 cell line. The p(TO) organo‐particle had the highest % apoptosis rate. At the 100 g mL −1 concentration, the fibroblast cell viability of p(ClO) and p(TO) organo‐particles was 176.46% and 107.78%, respectively. The IC50 value derived for the decrease in viability was determined as (2.22 mg mL −1 ) and it was calculated that it would kill the pancreatic cancer cells by 50% when doxorubicin and p(ClO) were administered combined.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".