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Record W4385973285 · doi:10.1016/j.cjco.2023.08.004

Progressive Reduction in Left Ventricular Mass on Serial Cardiac Magnetic Resonance Imaging in a 67-year-old Male Patient With AL-Amyloidosis

2023· article· en· W4385973285 on OpenAlexaff
Charles A. Lefkowitz, Εleni Andreou, Idan Roifman

Bibliographic record

VenueCJC Open · 2023
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicAmyloidosis: Diagnosis, Treatment, Outcomes
Canadian institutionsHealth Sciences CentreSunnybrook Health Science CentreToronto East General HospitalUniversity of Toronto
Fundersnot available
KeywordsMedicineAmyloidosisMagnetic resonance imagingCardiac amyloidosisCardiologyInternal medicineCardiac magnetic resonance imagingCardiac magnetic resonanceHeart failureAL amyloidosisRadiologyImmunoglobulin light chain

Abstract

fetched live from OpenAlex

This is a report of serial cardiac magnetic resonance (CMR) findings over 8 years in a 67 year old male with AL-amyloidosis. CMR at diagnosis showed 4 chamber involvement with a substantial increase in left ventricular (LV) mass. CyBor-D treatment resulted in complete remission with full recovery of functional capacity and CMR studies at 5 and 8 years show a progressive reduction in LV mass. To our knowledge, this is the longest CMR follow up study in a patient with cardiac AL-amyloidosis and illustrates the potential for substantial regression of cardiac amyloid protein when prolonged disease remission is achieved.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.327
Threshold uncertainty score0.882

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.255
Teacher spread0.248 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2023
Admission routes1
Has abstractyes

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