A Unique Case of Metastatic Recurrent Neuroendocrine Tumor in a Transplanted Liver Patient with Initial Diagnosis of Primary Well-Differentiated Intrahepatic Biliary Neuroendocrine Tumor
Bibliographic record
Abstract
Neuroendocrine tumors (NET) of biliary ducts are very rare, accounting for only 0.2-2% of all gastro-entero-pancreatic neuroendocrine tumors GEP NETs [1].More specifically, intrahepatic biliary neuroendocrine tumors are excessively rare, with few cases reported in medical literature so far.We present a very unusual case of a primary intra-biliary well differentiated NET, treated initially with SSA agents, Chemotherapy and liver directed procedures.Subsequently, the patient underwent liver transplant for liver-isolated disease.Unfortunately, two years later developed tumour recurrence in the liver as well as distant metastases involving the bone and adrenal gland, which were re-treated with SSA agent, re-challenge chemotherapy, and repeated liver directed therapies.The patient continues to have a favourable clinical course, currently awaiting systemic therapy with Lu177-Dotatate treatment.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.005 | 0.003 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".