Congenital central hypoventilation syndrome in children: a Hong Kong perspective
Bibliographic record
Abstract
Congenital central hypoventilation syndrome (CCHS), also known as Ondine's curse, is a central nervous system disorder involving failed autonomic control of breathing.2][3][4] As a sleep-related breathing disorder, CCHS causes ineffective breathing, apnoea, or respiratory arrest during sleep andrarely-wakefulness.The condition can be fatal if untreated.An infant with 'Ondine's curse' (a name based on a Greek myth about a curse that prevented breathing during sleep) was described in 1970. 5The term CCHS was first used in 1962 to describe symptoms in adults, 6 then later to describe symptoms in neonates. 7The current definition of CCHS includes diverse clinical manifestations.Paired-like homeobox 2B (PHOX2B) gene variants are the main causes of the syndrome; other causative variants are rare. 7Early diagnosis can prevent lifethreatening events and long-term sequelae.Better knowledge of CCHS and advances in genetics research will help affected patients to consistently receive early treatment, thereby improving survival and long-term outcomes.This article summarises current management of CCHS in children.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".