Congenital central hypoventilation syndrome in children: a Hong Kong perspective
Bibliographic record
Abstract
Congenital central hypoventilation syndrome (CCHS), also known as Ondine's curse, is a central nervous system disorder involving failed autonomic control of breathing. 2] The condition can be fatal if untreated. An infant with 'Ondine's curse' (a name based on a Greek myth about a curse that prevented breathing during sleep) was described in 1970. The term CCHS was first used in 1962 to describe symptoms in adults, 6 then later to describe symptoms in neonates. The current definition of CCHS includes diverse clinical manifestations. Paired-like homeobox 2B (PHOX2B) gene variants are the main causes of the syndrome; other causative variants are rare. Early diagnosis can prevent lifethreatening events and long-term sequelae. Better knowledge of CCHS and advances in genetics research will help affected patients to consistently receive early treatment, thereby improving survival and long-term outcomes. This article summarises current management of CCHS in children.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".