History of occupational asthma in Canada
Bibliographic record
Abstract
Canada has a long history of excellence and innovation in occupational asthma (OA). This article reviews its most significant achievements. Several Canadian clinical researchers were trained in part at the Brompton Hospital in London, UK, with Professor Jack Pepys, often referred to as the “father of occupational asthma.” They then settled in Canada in the 1970s and extended the British tradition in the study of OA. Important Canadian contributions as regards clinical aspects of diagnosis include:Improvement in the diagnosis by assessment of nonspecific bronchial responsiveness with pharmacological agents and of airway inflammation by examination of induced sputum, with methods developed and validated by the late Freddy Hargreave and colleagues, at McMaster University in Hamilton.Evaluation of several aspects of measurement of peak expiratory flow recordings.Improvement in the methodology of specific inhalation challenges with occupational agents.Furthermore, the outcome of OA was described, including its psycho-socio-economic aspects, and new scales of assessing impairment/disability proposed, then endorsed by international organizations. Prospective epidemiological studies were carried out, particularly in apprentices. The efficacy of surveillance programs was assessed. Many studies were carried out in workers exposed to Western red cedar on the west coast and snow-crab on the east coast. Irritant-induced asthma (nonimmunological OA) and variants of OA were also examined in original Canadian contributions. Canadian researchers have also played a major role as leaders of international conferences, as well as consensus documents and guidelines.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".