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Record W4386457006 · doi:10.1093/jcag/gwad012

The 2023 Impact of Inflammatory Bowel Disease in Canada: Mental Health and Inflammatory Bowel Disease

2023· review· en· W4386457006 on OpenAlexafffundabout
Lesley A. Graff, Rose Geist, M Ellen Kuenzig, Eric I. Benchimol, Gilaad G. Kaplan, Joseph W. Windsor, Alain Bitton, Stephanie Coward, Jennifer Jones, Kate Lee, Sanjay K. Murthy, Juan Nicolás Peña-Sánchez, Laura E. Targownik, Nazanin Jannati, Tyrel Jones May, Tasbeen Akhtar Sheekha, Tal Davis, Jake Weinstein, Ghaida Dahlwi, James Im, Jessica Amankwah Osei, Noelle Rohatinsky, Sara Ghandeharian, Quinn Goddard, Julia Gorospe, Shira Gertsman, Michelle Louis, Richelle Wagner, Colten Brass, Rhonda Sanderson, Çharles N. Bernstein

Bibliographic record

VenueJournal of the Canadian Association of Gastroenterology · 2023
Typereview
Languageen
FieldHealth Professions
TopicAdolescent and Pediatric Healthcare
Canadian institutionsUniversity of AlbertaMcMaster UniversityUniversity Health NetworkOttawa HospitalInstitute for Clinical Evaluative SciencesUniversity of OttawaMcGill University Health CentreMount Sinai HospitalUniversity of CalgaryCrohn's and Colitis CanadaUniversity of SaskatchewanHospital for Sick ChildrenPublic Health OntarioDalhousie UniversityUniversity of TorontoSickKids FoundationUniversity of Manitoba
FundersJanssen CanadaPfizer CanadaBristol-Myers Squibb CanadaAbbVie CanadaTakeda FoundationCrohn's and Colitis CanadaAmgen CanadaAmgenPfizerBristol-Myers Squibb
KeywordsMedicineAnxietyInflammatory bowel diseaseDepression (economics)Mental healthContext (archaeology)DiseaseUlcerative colitisPsychiatryPopulationCrohn's diseaseInternal medicineEnvironmental health

Abstract

fetched live from OpenAlex

Psychiatric disorders are 1.5 to 2 times more prevalent in persons with inflammatory bowel disease (IBD) than in the general population, with pooled prevalence estimates of 21% for clinical anxiety and 15% for depression. Rates are even higher when considering mental health symptoms, as nearly one-third of persons with IBD experience elevated anxiety symptoms and one-quarter experience depression symptoms. Rates of these symptoms were much higher during periods of disease activity, more common in women than men, and more common in Crohn's disease than ulcerative colitis. There is robust evidence of the detrimental effects of comorbid depression and anxiety on the subsequent course of IBD based on longitudinal studies tracking outcomes over time. However, psychiatric disorders and IBD have bidirectional effects, with each affecting risk of the other. Elevated mental health concerns have been consistently associated with greater healthcare utilization and costs related to IBD. There is some signal that low resilience in adolescence could be a risk factor for developing IBD and that enhancing resilience may improve mental health and intestinal disease outcomes in IBD. Psychological therapies used to treat anxiety and depression occurring in the context of IBD have been shown to significantly improve the quality of life for persons with IBD and reduce anxiety and depression. There is less evidence in regard to the impact of psychotropic medications on mental health or disease outcomes in persons with IBD. There is consensus, however, that mental health must be addressed as part of comprehensive IBD care for children and adults.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.317
Threshold uncertainty score0.987

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.002
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.031
GPT teacher head0.359
Teacher spread0.328 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations29
Published2023
Admission routes3
Has abstractyes

Explore more

Same venueJournal of the Canadian Association of GastroenterologySame topicAdolescent and Pediatric HealthcareFrench-language works237,207