Perioperative Management of Hemophilia A With Recombinant VIII-SingleChain: A Case Series
Bibliographic record
Abstract
Patients with hemophilia A often experience non-traumatic spontaneous bleeding and prolonged time to hemostasis following trauma. Those who require surgery must undergo risk assessment for perioperative bleeding, and factor VIII (FVIII) replacement therapy must be administered when coagulation factors are deficient to prevent perioperative bleeding. This case series reports the first four cases in which single-chain recombinant FVIII (rVIII-SingleChain) was used for perioperative hemostasis management in patients with hemophilia A at Hiroshima University Hospital, Hiroshima, Japan. Three male patients, aged 70, 66, and 77 years, with mild hemophilia A underwent four surgical procedures. After surgery, rVIII-SingleChain administration provided adequate increases in factor VIII activity, measured by the one-stage clotting assay (OSA), and hemostatic effectiveness was observed. This case series demonstrates that real-time changes in coagulation factor activity in the perioperative period can be monitored with the OSA after rVIII-SingleChain administration in patients with hemophilia A. J Curr Surg. 2022;12(1):15-20 doi: https://doi.org/10.14740/jcs455
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".