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Record W4386697793 · doi:10.1038/s41586-023-06501-x

Causes and consequences of child growth faltering in low-resource settings

2023· article· en· W4386697793 on OpenAlexaff
Andrew Mertens, Jade Benjamin‐Chung, John M. Colford, Jeremy Coyle, Mark J. van der Laan, Alan Hubbard, Sonali Rosete, Ivana Malenica, Nima S. Hejazi, Oleg Sofrygin, Weixin Cai, Haodong Li, Anna Nguyen, Nolan N. Pokpongkiat, Stephanie Djajadi, Anmol Seth, Esther Jung, Esther O. Chung, Wendy Jilek, Vishak Subramoney, Ryan Hafen, Jonas Häggström, Thea Norman, Kenneth H. Brown, Parul Christian, Benjamin F. Arnold, Souheila Abbeddou, Linda S. Adair, Tahmeed Ahmed, Asad Ali, Hasmot Ali, Per Ashorn, Rajiv Bahl, Maurício L. Barreto, Elodie Becquey, France Bégin, Pascal Bessong, Maharaj Kishan Bhan, Nita Bhandari, Santosh K. Bhargava, Zulfiqar A Bhutta, Robert E. Black, Ladaporn Bodhidatta, Delia B. Carba, William Checkley, Jean E. Crabtree, Kathryn G. Dewey, Christopher Duggan, Caroline Fall, Abu Syed Golam Faruque, Wafaie Fawzi, José Quirino da Silva Filho, Robert H. Gilman, Richard L. Guerrant, Rashidul Haque, S. M. Tafsir Hasan, Sonja Y. Hess, Eric R. Houpt, Jean H. Humphrey, Najeeha Talat Iqbal, Elizabeth Yakes Jimenez, Jacob John, Sushil Matthew John, Gagandeep Kang, Margaret Kosek, Michael S. Kramer, Alain Labrique, Sang Lee, Aldo Â. M. Lima, Tjale Cloupas Mahopo, Kenneth Maleta, Dharma Manandhar, Karim Manji, Reynaldo Martorell, Sarmila Mazumder, Estomih Mduma, Venkata Raghava Mohan, Sophie E. Moore, Robert Ntozini, Mzwakhe Emanuel Nyathi, Maribel Paredes Olórtegui, Césaire T. Ouédraogo, William A. Petri, Prasanna Samuel, Andrew M. Prentice, Najeeb Rahman, Manuel Ramírez‐Zea, Harshpal Singh Sachdev, Kamran Sadiq, Rajiv Sarkar, Monira Sarmin, Naomi Saville, Saijuddin Shaikh, Bhim P. Shrestha, Sanjaya K. Shrestha, Alberto M. Soares, Bakary Sonko, Aryeh D. Stein, Erling Svensen, Sana Syed, Fayaz Umrani, Honorine Ward, Keith P. West, Lee Wu, Seungmi Yang, Pablo Peñataro Yori

Bibliographic record

VenueNature · 2023
Typearticle
Languageen
FieldNursing
TopicChild Nutrition and Water Access
Canadian institutionsMcGill UniversityMcGill University Health Centre
FundersNational Institute of Allergy and Infectious DiseasesNational Institute of Diabetes and Digestive and Kidney DiseasesNational Heart, Lung, and Blood InstituteMedical Research Council
KeywordsWastingMedicineAnthropometryPopulationPediatricsPsychological interventionPregnancyLow birth weightHazard ratioDemographyChild developmentWeight for AgeChild mortalityEnvironmental healthConfidence intervalPsychiatryBiologyInternal medicine

Abstract

fetched live from OpenAlex

. Interventions such as nutritional supplementation during pregnancy and the postnatal period could help prevent growth faltering, but programmatic action has been insufficient to eliminate the high burden of stunting and wasting in low- and middle-income countries. Identification of age windows and population subgroups on which to focus will benefit future preventive efforts. Here we use a population intervention effects analysis of 33 longitudinal cohorts (83,671 children, 662,763 measurements) and 30 separate exposures to show that improving maternal anthropometry and child condition at birth accounted for population increases in length-for-age z-scores of up to 0.40 and weight-for-length z-scores of up to 0.15 by 24 months of age. Boys had consistently higher risk of all forms of growth faltering than girls. Early postnatal growth faltering predisposed children to subsequent and persistent growth faltering. Children with multiple growth deficits exhibited higher mortality rates from birth to 2 years of age than children without growth deficits (hazard ratios 1.9 to 8.7). The importance of prenatal causes and severe consequences for children who experienced early growth faltering support a focus on pre-conception and pregnancy as a key opportunity for new preventive interventions.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.466
Threshold uncertainty score0.272

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.262
Teacher spread0.254 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations115
Published2023
Admission routes1
Has abstractyes

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