Influence of blood pressure patterns on cognitive function in patients with Parkinson's disease
Bibliographic record
Abstract
Objective To investigate the effect of blood pressure patterns on memory function in patients with Parkinson's disease (PD). Methods A total of 68 PD patients were collected from the Department of Neurology of Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) between August 2018 and July 2021. All patients received 24 h ambulatory blood pressure monitoring (ABPM) and were divided into reverse dipping group (n=17), reduced dipping group (n=30), normal group (n=17), and extreme dipping group (n=4) according to the reduction rate of nocturnal systolic blood pressure; nocturnal hypertension group (n=37) and non⁃nocturnal hypertension group (n=31) according to nocturnal blood pressure. Global cognitive function was assessed by Mini⁃Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Memory function was evaluated by Logical Memory Test (LMT), Auditory Verbal Learning Test (AVLT) and Digit Span Test (DST). Results Among the 4 groups with different blood pressure pattern, statistical significances were found in duration (χ2=8.599, P=0.035), AVLT imediate 3 (F=3.100, P=0.033) and AVLT delayed (χ2=7.828, P=0.050). Pairwise comparison showed that the duration was longer in the reverse dipping group (Z=4.224, P=0.043) and the normal group (Z=4.821, P=0.028) than in the reduced dipping group; the AVLT imediate 3 of the reverse dipping group was lower than that of the normal group (t=⁃2.028, P=0.048) and the extreme dipping group (t=⁃2.673, P=0.010); the AVLT imediate 3 of the reduced dipping group was lower than that of the extreme dipping group (t=2.554, P=0.013). Compared with non⁃nocturnal hypertension group, the morbidity of hypertension was higher (χ2=6.399, P=0.011) and the duration was longer (Z=⁃2.008, P=0.045) in the nocturnal hypertension group. There was no significant difference in memory function between 2 groups (P＞0.05, for all). Conclusions PD patients with reverse dipping blood pressure pattern are more likely to influence cognitive function, especially in memory function. Continuous blood pressure monitoring should be performed in PD patients.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".