Evaluation of the effect of etamsylate on thromboelastographic traces of canine blood with and without the addition of heparin
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Bibliographic record
Abstract
The objective of this study was to investigate the effect of etamsylate on canine blood and heparinised canine blood from healthy dogs using thromboelastography (TEG).Citrated blood was obtained from twenty healthy client-owned dogs, and 3 experiments were performed.Experiment 1 compared TEG in blood versus blood with etamsylate (250 mM).Experiment 2 evaluated TEG in heparinised blood (1 U/mL) with and without the addition of etamsylate (250 mM).Experiment 3 evaluated dose escalation of etamsylate (control, 250 M, 500 M and 1000 M) in heparinised blood (1 U/mL).The addition of etamsylate to canine blood in experiment 1 increased the percentage of clot lysis at 30 min (z = -2.103,p = .035)and 60 min (z = -1.988,p = .047),suggesting that etamsylate could have a fibrinolytic effect.When etamsylate was added to heparinised canine blood (1 U/mL), etamsylate produced a dosedependent inhibition of the effect of heparin when higher concentrations of etamsylate were used (500 M and 1000 M).The linear mixed effects model showed significant increases in angle and maximal amplitude when high dose etamsylate was added compared to the control.In conclusion, etamsylate could be used at higher doses to inhibit the effect of heparin in dogs when protamine might not be available.However, etamsylate might have a fibrinolytic effect when used in healthy dogs.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it