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Record W4386982522 · doi:10.1007/978-3-031-18810-7_3

Molecular Radiation Biology

2023· book-chapter· en· W4386982522 on OpenAlexaff
Judith Reindl, Ana Margarida Abrantes, Vidhula Ahire, Omid Azimzadeh, Sarah Baatout, Ans Baeyens, Bjorn Baselet, Vinita Chauhan, Fabiana Da Pieve, Wendy Delbart, Caitlin Pria Dobney, Nina Frederike Jeppesen Edin, Martin Falk, Nicolas Foray, Agnès François, Sandrine Frelon, Udo S. Gaipl, Alexandros G. Georgakilas, Olivier Guipaud, Michael Hausmann, Anna Michaelidesová, Munira Kadhim, Inês A. Marques, Mirta Milić, Dhruti Mistry, Simone Moertl, Alegría Montoro, Elena Obrador, Ana Salomé Pires, Roel Quintens, Nicholas Rajan, Franz Rödel, Peter K. Rogan, Diana Savu, Giuseppe Schettino, Kevin Tabury, Georgia I. Terzoudi, Sotiria Triantopoulou, Kristina Viktorsson, Anne‐Sophie Wozny

Bibliographic record

Venuenot available
Typebook-chapter
Languageen
FieldMedicine
TopicEffects of Radiation Exposure
Canadian institutionsWestern UniversityUniversity of TorontoHealth Canada
Fundersnot available
KeywordsBiologyEpigeneticsDNA damageRadiosensitivityFunction (biology)DNA repairComputational biologyDamagesCell biologyRadiation resistanceCellDNAGeneticsRadiationGeneRadiation therapyMedicine

Abstract

fetched live from OpenAlex

Abstract Various exogeneous and endogenous factors constantly cause damages in the biomolecules within a cell. For example, per day, 10,000–100,000 molecular lesions occur in DNA per cell. The molecule modifications that are formed disturb the structure and function of the affected molecules. The purpose of this chapter is to introduce the damages to biomolecules caused by radiation, the associated repair pathways, and the effect on the cellular function. Special interest lies on the damages induced to DNA, the carrier of the human genome, and the consequence to genomic integrity, cell death, and cell survival. Additionally, related effects regarding inflammation and immunity, epigenetic factors, and omics are discussed. The chapter concludes with an explanation of the molecular factors of cellular hyper-radiosensitivity and induced radiation resistance.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesInsufficient payload (model declined to judge)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.927
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.276
Teacher spread0.263 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations9
Published2023
Admission routes1
Has abstractyes

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Same topicEffects of Radiation ExposureFrench-language works237,207