Liver-Type Fatty Acid Binding Protein (FABP1) Has Exceptional Affinity for Minor Cannabinoids
Bibliographic record
Abstract
Fatty acid binding protein 1 (FABP1) is a lipid transporter primarily expressed in the liver where it helps move fatty acids between lipid membranes. Inhibition of FABP1 has potential therapeutic implications for nonalcoholic fatty liver disease, metabolic syndrome & obesity, diabetes, and inflammatory & cardiovascular diseases. Curiously, FABP1 is known to bind to both endocannabinoids (ECs) and the major phytocannabinoids (PCs) with moderately high affinities. We have developed an in-silico model of the protein and validated it against experimental data. We then employed the model to predict the binding mode and affinities of minor cannabinoids (MCs) to FABP1. Our study predicts that the top ranked MCs 5-acetyl-4-hydroxy-CBG and CBGA bind stronger than fatty acids (FAs), ECs or PCs, and participate in the key interactions used to stabilize FABP1-FA complexes. This makes them promising starting points for the development of new therapeutics. The implications this has on considering the minor cannabinoids as low entropy isosteres of the fatty acids is also discussed.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".