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Record W4387041379 · doi:10.1016/s2666-5247(23)00288-4

Investment in biosafety and biosecurity: the need for a risk-based approach and systematic reporting of laboratory accidents to mitigate laboratory-acquired infections and pathogen escapes

2023· article· en· W4387041379 on OpenAlexfundno aff
Stuart D. Blacksell, Kathrin Summermatter, Zibusiso M. Masuku, Kazunobu Kojima, Emma Ross, David R. Harper, Keith Hamilton

Bibliographic record

VenueThe Lancet Microbe · 2023
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicBacillus and Francisella bacterial research
Canadian institutionsnot available
FundersGlobal Affairs CanadaWellcome TrustWorld Health Organization
KeywordsBiosafetyBiosecurityRisk analysis (engineering)ScopusLaboratory safetyBusinessEnvironmental healthMedicineBiotechnologyPolitical scienceMEDLINEBiologyPathology

Abstract

fetched live from OpenAlex

In the realm of high-consequence pathogens, laboratory-acquired infections (LAIs) and accidental pathogen escapes from laboratories can have far-reaching and severe implications for individuals, animals, and the environment. These occurrences are a great concern for a wide range of stakeholders, including laboratory workers, managers, those in the scientific research community and industry, policy makers, political leaders, and the general public. It is vitally important to take all necessary measures to mitigate the risks associated with such occurrences as the consequences of these events can be significant and long-lasting.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.115
metaresearch head score (Gemma)0.225
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: Reporting · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: none
Teacher disagreement score0.885
Threshold uncertainty score0.610

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.1150.225
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0050.002
Science and technology studies0.0040.009
Scholarly communication0.0180.017
Open science0.0070.012
Research integrity0.0130.017
Insufficient payload (model declined to judge)0.0060.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.021
GPT teacher head0.281
Teacher spread0.260 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designTheoretical or conceptual
DomainReporting
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations12
Published2023
Admission routes1
Has abstractyes

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