Investigation Of The Effects Of Rapid Heat Acquisition And Desloratadine On Hematological Profiles Of Firefighters
Bibliographic record
Abstract
Previous research has shown increased platelet counts amongst firefighters exposed to rapid heat stress. However, the extent to which thermal strain contributes to immune responses (i.e., white blood cell count) in structural firefighters (SFF) warrants further investigation. Furthermore, whether desloratadine, an H1 antihistamine, can influence the heat-induced immune response remains to be investigated. PURPOSE: To evaluate the impact of rapid exertional heat stress (EHS) on SFF’s white blood cell (WBC) and platelet (PLT) count, and whether desloratadine influences the hematological response. METHODS: In two separate sessions, five male SFFs (Age: 31.6 +/- 6.44 yrs; Height: 1.91 +/- 0.06 m; Weight 94.83 +/- 12.53 kg; VO2max: 49.96 +/- 6.52 ml/kg/min) walked on a treadmill in structural firefighting protective equipment at 3.0 mph with a 5% incline until reaching volitional maximum or a core temperature (Tc) of 39.5 °C. Participants ingested 10 mg drug/placebo and a Tc capsule 2 hours prior to each session, with an identical drug/placebo dose 24 hours later. Venous blood samples were obtained immediately before, after, and 2-, 24-, 48-, and 72-hours post-heating. RESULTS: Tc increased by a mean of 1.89 +/- 0.44 °C during EHS. No significant differences between drug and placebo were observed for WBC; PLT; and number of lymphocytes (LY), monocytes (MO), neutrophils (NE), eosinophils (EO), and basophils (BA) (p > 0.05). All WBC, PLT, LY, MO, NE, EO, and BA showed significant differences over time following EHS (p < 0.05). Significant elevations in WBC, PLT, LY, & NE were found between baseline and either immediately post or 2 hours post testing (p < 0.05). In both conditions WBC count increased post-test by 36.02-42.35% from baseline (p < 0.05) and continued to increase to 68.76-87.17% 2 hours post-test (p < 0.05). By contrast, PLTs post-test increased by 45.13-49.80% from baseline (p < 0.05) and saw a recovery to 2.56-11.83% above baseline within 2 hours. CONCLUSION: EHS significantly impacts WBC markers and PLT counts within 72 hours post exposure. Desloratadine does not appear to influence these hematological responses.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".