Impact Of High-intensity Interval Training On Spontaneous Sympathetic Transduction In Healthy Younger Adults
Bibliographic record
Abstract
Peak blood pressure responses to spontaneous bursts of muscle sympathetic nerve activity (MSNA; sympathetic transduction) are inversely associated with aerobic fitness in young males, but not young females. However, no study has examined the impact of an aerobic exercise training intervention on sympathetic transduction in young healthy adults. PURPOSE: To test the hypothesis that a 12-week high-intensity interval training (HIIT) intervention would improve aerobic fitness and attenuate sympathetic transduction versus a Control group. METHODS: 19 healthy younger adults were randomly assigned to a HIIT (n = 11, 7♀, 25 ± 7 years, 23.6 ± 2.4 kg/m2) or Control (n = 8, 4♀, 23 ± 1 years, 23.2 ± 2.5 kg/m2) group. Aerobic fitness was determined as relative peak oxygen consumption (V̇O2peak, indirect calorimetry) from a graded, maximal cycling test. Common peroneal MSNA (microneurography) and beat-by-beat diastolic blood pressure (DBP, finger photoplethysmography) were recorded for ~10-min during supine rest. Peak DBP increases following all MSNA bursts were used to quantify sympathetic transduction. Nadir DBP following heartbeats without MSNA bursts were also determined. All assessments were repeated after the 12-week HIIT/Control periods. HIIT (3d/week) consisted of 2, ~20-min bouts of 15 s:15 s alternating between 100% peak aerobic power: passive recovery. Each bout was separated by 5-min of passive recovery. RESULTS: HIIT improved V̇O2peak (38.2 ± 7.6 to 44.2 ± 8.3 mlO2/kg/min, P < 0.001), which was unchanged in the Control group (P = 0.304). In addition, resting MSNA burst frequency and DBP were unchanged following HIIT or Control periods. Sympathetic transduction was similar following HIIT (+1.2 ± 0.5 versus +1.4 ± 0.4 mmHg) or Control (+1.3 ± 0.8 versus +1.3 ± 0.6 mmHg) periods (Interaction P = 0.692). However, nadir DBP responses to non-MSNA heartbeats were enhanced following HIIT (-0.5 ± 0.2 versus -0.7 ± 0.2 mmHg, P = 0.005), but unchanged in the Control group (-0.6 ± 0.6 versus -0.5 ± 0.4 mmHg, P = 0.310). CONCLUSIONS: These results indicate that HIIT-mediated increases in aerobic fitness did not alter the pressor response to spontaneous MSNA in a group of younger males and females but may have enhanced local vascular autoregulatory control following heartbeats absent MSNA bursts.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".