Impact Of Aerobic Fitness On Lower-limb Resistance Vessel Function Following A Prolonged Bout Of Uninterrupted Sitting
Bibliographic record
Abstract
Prolonged sitting reduces lower-limb resistance vessel function (RVF). In contrast, increasing levels of aerobic fitness enhances lower-limb RVF. However, it is unknown if higher aerobic fitness can protect against prolonged sitting-induced declines in RVF. PURPOSE: To investigate the impact of aerobic fitness on sitting-induced reductions in lower-limb RVF. METHODS: In 8 healthy young adults (6♀, 22 ± 2 years), aerobic fitness was assessed via indirect calorimetry as the relative peak oxygen consumption (V̇O2peak) attained from a graded, maximal cycling test (37.5 ± 8.7 mlO2/kg/min, range: 27.7-50.2 mlO2/kg/min). Popliteal blood flow (mL/min) and beat-by-beat arterial pressure (mmHg) were recorded via duplex ultrasonography and finger photoplethysmography, respectively. Popliteal vascular conductance (PVC, mL/min/mmHg) was calculated as blood flow/mean arterial pressure. Lower-limb RVF was assessed in the seated posture and quantified as the peak PVC and PVC area under the curve (PVCAUC, first minute of hyperemia) responses to 5-min of distal cuff-induced ischemia. The lower-limb RVF assessment was performed before and after a ~ 3-hour bout of uninterrupted sitting. RESULTS: Peak PVC decreased following sitting (659 ± 125 to 452 ± 170 mL/min/mmHg, P = 0.05), while PVCAUC remained unchanged (105 ± 35 versus 87 ± 21 mL/mmHg, P = 0.17). Relative V̇O2peak was not associated with Pre-Sitting Peak PVC (R = 0.226, P = 0.626) or PVCAUC (R = -0.022, P = 0.963). Relative V̇O2peak was also not associated with sitting-induced reductions in Peak PVC (R = 0.269, P = 0.560). CONCLUSIONS: The post-sitting reductions in Peak PVC support previous work demonstrating that prolonged uninterrupted sitting negatively impacts lower-limb RVF. In contrast, prolonged sitting did not alter the PVCAUC response. This suggests that Peak PVC responses may provide a more sensitive index of sitting-induced declines in RVF. In young, healthy individuals, aerobic fitness did not impact baseline or sitting-induced reductions in lower-limb RVF.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".