Effects Of Collagen Peptide Supplementation On Biomarkers Of Connective Tissue Turnover: CTX/P1NP Ratio
Bibliographic record
Abstract
BACKGROUND: Connective tissue (CT) dysfunction is a hallmark of aging, with decreased tissue turnover leading to decrements in body-wide structure and function. While age related tissue turnover in muscle and bone is associated with declines in synthesis, recent evidence using deuterium in adult compared to aged mice suggests collagen remodeling declines with age due to decreased degradation rather than synthesis of collagen fibrils. This results in stiff fibrotic CT with diminished force production and high susceptibility to injury and disease. Collagen peptides (CP) are thought to exert positive effects on bone and connective tissue remodeling. Serum C-terminal telopeptide (CTX) and procollagen type-I N-terminal propeptide (P1NP) are measures of bone and collagen turnover and are strongly correlated with changes in bone mineral density. Although, directionality is dependent on intervention and mechanisms of action, and tissue measured. Therefore, the purpose of this double-blind randomized placebo-controlled trial was to characterize the effects of daily consumption of CP (SOLUGEL®) over 6-months on CTX and P1NP concentrations in middle-aged active adults. METHODS: Participants (N = 58) were randomized into 3 groups: 20 g/d CP (n = 19), 10 g/d CP (n = 19), or placebo (n = 20). Serum was collected at baseline, 3 months, and 6 months to assess changes over time in CTX and P1NP. A mixed model ANOVA was used to assess CTX/P1NP ratio. Pairwise comparisons were used for post hoc analyses of significant interactions with Bonferroni correction for multiple comparisons. Data are mean ± standard deviation. RESULTS: A significant interaction between the treatments and time on CTX/P1NP concentrations was observed, F(4, 110) = 3.552, p = .009, ηp2 = .114. CTX/P1NP levels significantly increased from baseline (.00658 ± .00288 ng/mL) to 6 months (.00879 ± .00287 ng/mL) in the 10 g/d group (p = .001). No significant changes were observed in the 20 g/d or placebo groups. CONCLUSIONS: Six months of daily collagen peptide supplementation of 10 g, but not 20 g or placebo, yielded significant increases in CTX/P1NP ratio. These findings suggest 10 g/d is effective for promoting collagen turnover. Therefore, CP supplementation may play an important role in tissue growth and repair via connective tissue remodeling.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".