MétaCan
Menu
Back to cohort
Record W4387141906 · doi:10.3389/fsybi.2023.1255472

Synthetic biology encompasses metagenomics, ecosystems, and biodiversity sustainability within its scope

2023· article· en· W4387141906 on OpenAlexafffund
David B. Levin, Nediljko Budiša

Bibliographic record

VenueFrontiers in Synthetic Biology · 2023
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGene Regulatory Network Analysis
Canadian institutionsUniversity of Manitoba
FundersNational Academy of Agricultural SciencesNatural Sciences and Engineering Research Council of CanadaCanada Research Chairs
KeywordsMetagenomicsSustainabilityBiodiversityBiosphereSynthetic biologyScope (computer science)EcosystemEcologyEnvironmental resource managementBiologyComputer scienceComputational biologyEnvironmental science

Abstract

fetched live from OpenAlex

We envision the convergence of synthetic biology (SynBio) and metagenomics as a significant development for the engineering of complex biological systems. The entire biosphere with its diverse life forms can also be considered as a reservoir for evolutionary innovations and a source of modules for SynBio. Metagenomics, which is a large part of biodiversity, should be considered as an important source of modules. The abstraction hierarchy of amalgamating SynBio and metagenomics (“synthetic metagenomics”) entails the standardized integration of parts, devices, circuits, and modules into functional chassis. These principles transcend the boundaries of single cell design and apply to the engineering of biodiversity sustainability in multicellular entities, their interconnections, and their dynamics in communities and whole ecosystems. Examples include applications in environmental sustainability, such as analysis of antimicrobial resistance in waste management, bioremediation of oil spills, and degradation of plastics. Future research and experimental interventions will ultimately provide a strong link between bioengineering, metagenomics, microbial consortia, ecosystems, and biodiversity sustainability under the umbrella of synthetic biology.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.778
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.238
Teacher spread0.228 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations10
Published2023
Admission routes2
Has abstractyes

Explore more

Same venueFrontiers in Synthetic BiologySame topicGene Regulatory Network AnalysisFrench-language works237,207