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Record W4387312423 · doi:10.1038/s41575-023-00838-4

Precision medicine in monogenic inflammatory bowel disease: proposed mIBD REPORT standards

2023· review· en· W4387312423 on OpenAlexafffund
Holm H. Uhlig, Claire Booth, Judy H. Cho, Marla C. Dubinsky, Anne M. Griffiths, Bodo Grimbacher, Sophie Hambleton, Ying Huang, Kelsey Jones, Jochen Kammermeier, Hirokazu Kanegane, Sibylle Koletzko, Daniel Kotlarz, Christoph Klein, Michael J. Lenardo, Bernice Lo, Dermot McGovern, Ahmet Özen, Lissy de Ridder, Frank M. Ruemmele, Dror S. Shouval, Scott B. Snapper, Simon Travis, Dan Turner, David C. Wilson, Aleixo M. Muise

Bibliographic record

VenueNature Reviews Gastroenterology & Hepatology · 2023
Typereview
Languageen
FieldImmunology and Microbiology
TopicImmunodeficiency and Autoimmune Disorders
Canadian institutionsSickKids FoundationUniversity of Toronto
FundersCelgeneMedical Research CouncilNational Institutes of HealthNational Institute of Diabetes and Digestive and Kidney DiseasesZonMwCanadian Institutes of Health ResearchIFM TherapeuticsUCB PharmaRegeneron PharmaceuticalsGilead SciencesPfizerEli Lilly and Company
KeywordsMedicineObservational studyInflammatory bowel diseasePrecision medicineIntensive care medicineRandomized controlled trialDiseaseClinical trialMEDLINEPersonalized medicineInternal medicineBioinformaticsPathology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.015
metaresearch head score (Gemma)0.012
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: Reporting · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: none
Teacher disagreement score0.985
Threshold uncertainty score0.077

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0150.012
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0030.002
Bibliometrics0.0030.002
Science and technology studies0.0010.002
Scholarly communication0.0040.004
Open science0.0030.003
Research integrity0.0040.006
Insufficient payload (model declined to judge)0.0040.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.021
GPT teacher head0.334
Teacher spread0.313 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
DomainReporting
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations22
Published2023
Admission routes2
Has abstractno

Explore more

Same venueNature Reviews Gastroenterology & HepatologySame topicImmunodeficiency and Autoimmune DisordersFrench-language works237,207