Remimazolam as an Adjunct to General Anesthesia During Spine Surgery in Adolescents
Bibliographic record
Abstract
Background: Remimazolam is a benzodiazepine that has recently been released for clinical use. Similar to midazolam, it has sedative, anxiolytic, and amnestic properties. However, its metabolism is different as it undergoes metabolism by tissue esterases with a half-life of 5 - 10 min and a limited context-sensitive half-life. Methods: We retrospectively reviewed our experience with the use of remimazolam as an adjunctive to general anesthesia during spine surgery. Results: The study cohort included 40 patients, ranging in age from 11 to 35 years and in weight from 21 to 126 kg. Remimazolam was added as an adjunct to maintenance anesthesia with propofol, desflurane, or dexmedetomidine/ketamine at a starting dose of 2.5 - 10 µg/kg/min (median dose 5 µg/kg/min). Maintenance doses ranged from 1.5 to 30 µg/kg/min (median dose 8 µg/kg/min). Remimazolam was infused for an average of 5.1 h per patient or a total of 203 h of infusion in the 40 patients. With the infusion of remimazolam, the requirements for the volatile agent or propofol were decreased by approximately 40-50%. No adverse effects related to remimazolam were noted. Conclusions: Remimazolam is an effective adjunct to general anesthesia during spinal surgery, resulting in a significant decrease in requirements for propofol or volatile anesthetic agents. J Curr Surg. 2023;13(1):1-5 doi: https://doi.org/10.14740/jcs472
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".